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Phage Therapy against β-hemolytic Streptococcicosis of Japanese Flounder Paralichthys olivaceus : ヒラメのβ溶血性レンサ球菌症に対するファージ治療試験
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Matsuoka, Satoru | - |
dc.contributor.author | Hashizume, Takaya | - |
dc.contributor.author | Kanzaki, Hiroyuki | - |
dc.contributor.author | Iwamoto, Emi | - |
dc.contributor.author | Park, Se Chang | - |
dc.contributor.author | Yoshida, Terutoyo | - |
dc.contributor.author | Nakai, Toshihiro | - |
dc.date.accessioned | 2009-08-12T08:19:37Z | - |
dc.date.available | 2009-08-12T08:19:37Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Fish Pathol., 42, 181-189 | en |
dc.identifier.issn | 0388-788X (print) | - |
dc.identifier.issn | 1881-7335 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/7048 | - |
dc.description.abstract | We examined the therapeutic effect of Streptococcus iniae phages isolated from fish culture environments against experimental streptococcicosis of Japanese flounder Paralichthys olivaceus. Phage sensitivity tests with a double agar method revealed that 31 of 35 S. iniae strains from the flounder have a similar sensitivity to six phage isolates. In phage therapy experiments, fish were injected intraperitoneally (IP) with S. iniae PSi402 and 1 h later IP-injected with a mixture of two or four phage isolates, and observed at 25°C for 2 wk. Mortalities of fish receiving phages were significantly lower than those of control fish without phage-treatment in all four trials. The effect of phage treatment was also demonstrated even at 24 h post-infection, when cell numbers of S. iniae were 107.4 and 104.5 CFU/g in the kidneys and brains of fish, respectively. However, as phage-resistant S. iniae were frequently isolated from dead fish in the phage-treated group, further investigations are required to establish phage therapy of the disease. | en |
dc.language.iso | ja | - |
dc.publisher | Japanese Society of Fish Pathology | en |
dc.subject | bacteriophages | en |
dc.subject | phage therapy | en |
dc.subject | β-hemolytic streptococcicosis | en |
dc.subject | Streptococcus iniae | en |
dc.subject | Paralichthys olivaceus | en |
dc.subject | Japanese flounder | en |
dc.title | Phage Therapy against β-hemolytic Streptococcicosis of Japanese Flounder Paralichthys olivaceus | en |
dc.title.alternative | ヒラメのβ溶血性レンサ球菌症に対するファージ治療試験 | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박세창 | - |
dc.identifier.doi | 10.3147/jsfp.42.181 | - |
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