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선청성 세포비대성 바이러스감염에 수반된 Ganglionic Eminence Cyst에 의해 유발된 수뇌증 : Hydrocephalus caused by Ganglionic Eminence Cyst in Congenital Cytomegalovirus Infection

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서연림; 지제근

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서울대학교 의과대학
Seoul J Med, Vol.24 No.3, pp. 341-346
An autopsy case of hydrocephalus whicb is presumably
caused by partial obstruction of Foramen
Monroe in association with congenital cytomegalovirus
infection is reported.
This male baby was born to a 23 year old primiparous
mother after 36 weeks gestation. The
pregenancy ''I:a5 uneventful except for a gradual
enlargement of fetal head from the Sth month of
gestation. After birth through Cesarian section
because of breech presentation, the baby developed
marked cyanosis and respiratory distress and died
60 hours later.
Postmortem examination revealed right cleft lip
and palate, abnormal lobation of lung and hepatosplenomegaly.
Coronal sections of brain revealed
partial obstruction of foramen Monroe by ganglionic
eminence cyst and dilation of lateral ventricles. The
3rd and 4th ventricles were not dilated.
Characteristic cytomegalic inclusion bodies were
seen III the kidneys, liver, pancreas and lungs,
together with a marked extramedullary hematopoiesis
in viscera. Interstitial pneumonitis and bronchopneumonia
were also noted.
The microsopic findings of the brain consisted of
periventricular white matter damage, i.e., hypertrophic
astrocytosis, rarefaction and capillary proliferation.
The ganglionic eminence cyst consisted of multiple
trabeculae with wasted matrix cells and some degree
of gliosis. No inclusion body was seen in ependymal
or glial cells. A small focus of calcification below
the ependyma was present.
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