N-methyl-N'-nitro-N-nitrosoguanidine 경구 투여에 의하여 발생한 흰쥐 전위의 편평 상피성 종양 -병리조직학적 관찰을 통한 편평 상피종양의 조직발생 추정 -
A Histopathologic Observation on Squamous Cell Neoplasm of the Forestomach in Rats by Peroral Administration of N-methyl-N'-nitro-N-nitrosoguanidine
- 김우호; 김용일; 김진복
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.4, pp. 371-379
- A histopathologic study on experimentally induced
squamous cell neoplasm of the forestomach in rats
by peroral administration of N-methyl-N'-nitro-Nnitrosoguanidine(
MNNG) was carried out to clarify
the morphologic characteristics and nature of its
carcinogenesis. A total of 160 rats were divided into
two groups: 130 of experimental group were administered
with drinking water containing 83ug/ml
MNNG, and 30 control rats with distilled water.
After 37 weeks of exposure to MNl'\G, the animals
were sacrified and examined.
Among the 130 experimetal group, 100 survived
more than 32 weeks. Squamous cell papillomas were
found in 24 rats(24%). and squamous cell carcinoma
in 4 rats (4;'6), one of which was carcinoma in situ.
Besides the neoplastic growth, reactive proliferation
of the squamous cells such as acanthosis.
hyperkeratosis and perakeratosis were frequent
associations with or without atypical changes of the
basal cells. The possible relationship between these
reactive and neoplastic lesions was discussed based
on the finding that all experimental animals start
with the development of benign reactive and proliferative
changes which are subsequently accompanied
by cellular atypism as well as papillomatous
growth to result in carcinomatous transformation.
The proposed histogenesis was compared with that
in glandular stomach.