Compartment Model을 이용한 정략적인 신장기능 해석에 관한 연구

Abstract

A new method for estimation of the renal functiolL was developed using three-comparts model analysiswith gamma camera system. The rate constants of the plasma flows between the compartments were obtained from the time activity curves of three regions of interest (ROO. the aorta, the left and right kidney. The ratio of these rate constants was shown to be proportional to the ratio of the glomerular Jletration rate (GFR) to the effective renal plasma flow (ERPF), thus providing the estimated filtration fraction (FF). In 50 normal subjects, the ratio of the rate constants (k 3/k, or k,/k,) was O. 19±0. 04 for left kidney and O. 19±0. 05 for right kidney. In 25 patients with abnormal renal function, these ratios were larger than those in normal groups (0. 33±0. 09) or smaller (0.1l±0.02). This method is simpler and more non-invasive than other methods. And it provides a quantitative evaluation method of the renal function.