인삼이 간세포 약물대사효소의 활성도에 미치는 영향

Abstract

A study was carried out to observe the influence of gins(:ng on the activity of microsomal drug-metabolizing enzyme system in mOUS2 liver. GiJ1s,~ng saponin fraction, when given to male -dult C;;IJf mice for 7 days in the dosages of 10 mg ikg and lOOmg/kg, stimulated the metabolism of zoxaz olami nc by the l i vcr 9000 Xg supernatant, but it did not affect the rate of pentobarbital metabolism. The duration of zoxazolami nc paralvsis as "...·ell as panto barbital hypnosis in the intact animal, however, somewhat shortened by ginseng saponin. It was found that pretreatment of mouse with ginseng saponin caused an increase in the activity of hepatic microsomal enzyme system which metabolizes zoxazolamine and was paralled in vivo by a shortened duration of zoxazolamine paralysis. The ability of ginseng saponin to shorten the duration of pentobarbital hypnosis in the intact mice was not paralled by a pentobarbital metabolism by the liver 9000X g supernatant. 1t can not be excluded from this point that the central stimulant effect of ginseng may functionally antagonize the hypnotic action of pentobarbital.