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Studies on Filariasis in Korea -Status Survey and Chemotherapy in Cheju Do*- : 한국의 사상충증에 관한 연구

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Seo, Byong-Seol

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서울대학교 의과대학
Seoul J Med, Vol.17 No.2, pp. 83-95
1. Based on the data collected through the
night blood surveys during the period of 1972
to 1975 in Cheju Do, the present status of
malayan filariasis in the island was analyzed,
reviewed and compared with the results
obtained in the previous survey during the
past decade.
2. The present survey revealed that among
5,681 persons examined in the areas of seven
Myons and two Eups, 149(2.6%) were found
infected with Brugia malayi, And the mean
microfilaria densi ty was 1. 40 per cmm of
According to the geographic distribution by
villages, the south-eastern portion showed a
slightly higher rate of infection. From the
distribution of the positives by age, the infection
rate rapidly increased at the age of 20-29
years and reached to a peak of 6. 6 per cent at
the age of 40-49.
3. Compared to the present data with those
collected from 1963 to 1964 by Seo et aI. (1965),
the overall infection rate distinctly decreased
from 8.6 to 2.6 percent and the microfilaria density
also fell from 1. 91 to 1. 40 per cmm
of blood. Especially, at certain villages in the
south-eastern section of the island where
mass treatment has been conducted, such as
Namwon, Pyosun etc., the remarkable decreaaes
in the rate of infection and microfilaria
density have been recognized. This has been
proved also in the decreased rates of natural
infection of mosquito, Aedes togoi with
mature larva of B. malayi. In the village of
Namwon Myon, the natural infection rate of
A. togoi decreased from 8.8 per cent at 1970
before mass treatment, up to O. 33 per cent at
1975 after treatment.
4. An attempt to revise the dosage schedule
by diethylcarbamazine and to make the drug
more practicable in the mass treatment was
made. The half conventional dose, 3 mg/kg
'of diethylcarbamazine daily 12 times, totaling
36 mg/kg was chosen as a chemotherapeutic
The treatment response was analyzed on the
basis of the negative conversion and reduction
rates of microfilariae in the blood. Twenty-one
'Out of 38 positive cases given the above doses
were converted negative after the first 18 mgt
kg doses at the seventh day of treatment.
Twelve out of 15 cases who undertook the
follow-up study up to 250th day after treatment
were completely cleared from microfilariae
in the blood by a total dosage of 36 mg/kg.
5. Three dosage schedules, the conventional
-dosage (6mg/kg daily, 12 times), the low
dosage (0. 5, 1, 2, 4, 6 mg/kg daily boosted
'6 mg/kg up to four times) and the half
'Conventional dosagetS mg/kg daily, 12 times)
were compared each other in their effectiveness.
The negative conversion rate as well as
the microfilaria reduction rate in the low
dosage schedule was slightly higher than the
others. However, it is assumed that the half
conventional dose may also quite effective as a smaller dose schedule.
It is practically recommended that the half
conventional dose may also be employed in
the mass treatment of the cases with low
microfilaria density.
6. The minimum dosage to clear microfilariae
of B. malayi from blood in Cheju Do
seems to be good enough with the dose, of 36
mg/kg of diethylcarbamazine.
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