일부 무의촌지역과 도시에서 분리한 S. pneumoniae의 항균제 감수성에 관한 연구

Abstract

64 strains of S. pneumoniae isolated from the residents of doctorless areas in Korea from Aug. 1976 to Jan. 1977 and 62 strains of S. pneumoniae isolated from the children in Seoul at Mar, 1977 were examined for susceptibility to 14 antimicrobics by agar dilution method. The susceptibility of two groups to each antimicrohies were compared and incidence of resistant strains in each antimicrobics and correlation in the antimicrobic susceptibility of 126 strains of S. pneumoniae among 14 antimicrobics were analyzed. 1. The mean MIC's of Carbenicillin and Kanamycin to the S. pneumoniae isolated from Seoul were 9.8 and 1. 7 times higher than those to the S. pneumoniae isolated from doctoress areas respectively. 2. There were no significant differences in susceptibility to Penicillin, Ampicillin, Cephalexin, Tetracycline, Oxytetracycline. Doxycycline, Minocycline, Gentamicin, Streptomycin, Erythromycin, Cotrimoxazole, and Troleandomycin respectively between S. pneumoniae isolated from doctorless areas and Seoul. 3. Incidence of resistant strains in S. pneumoniae isolated from doctorless areas was the highest with KanamycinC79.7%) followed by TetracyclineC73. 3%), Oxytetracycline(67.2%), Streptomycin(48.4%) Doxycycline( 42.0%) Minocycline(31. 3%), Gentamicin (28.1%), Carbenicillin (4. 7%) CotrimoxzoleC3.1%), Troleandomycin(I. 6%), and Cephalexin(I. 6%). There were no strains resistant to Penicillin. Ampicillin, or Erythromycin. 4. Incidence of resistant strains in S. pneumoniae isolated from Seoul was the highest with Kanamycin (90.3%). followed by Tetracyc1ine(87.0%) CarbenicillinC74.2%), Oxytetracyc1ineC66. 2%), Streptomycin (61. 3%), Minocycline(33.8%), Gentamicin (24. 2%), and Doxycycline(3. 2%). There were no strains resistant to Penicillin, Ampicillin, Cephalexin, Cotrimoxazole, or Troleandomycin. 5. There were significant differences in the incidence of resistant strains between two groups of S. pneumoniae with Carbenicillin and Doxycycline. 6. There were high correlation in susceptibility of 126 strains of S. pneumoniae among Tetracyline, Oxytetracycline. Doxycycline and Minocyclnet correlation coefficient ranged between 0.86 to 0.95), but there were no significant correlation in susceptibility of S. pneumoniae among Penicillin, Ampicillin, Carbenicillin, and Cephalexin(correlation coefficient ranged between O. 01 to O. 38). Correlation coeffieient of susce-ptibility of S. pneumoniae between Kanamycin and Streptomycin was 0.68.