Clinical Trial on Reversible Male Contraceptive With Long-Acting Sex Hormones

Abstract

In conclusion, for the development of an ideal method of reversible male contraceptive using sex hormones, a new combination with the lowest dosage of Depo- Provera and Depo-Testosterone should be developed by which full suppression of spermatogenesis could be attained in a limited period of time since occasional pregnancies had been documented with the sperm counts of less than 10 milliori/ml. The combined steroids compounds used in this trial suppress sperm production to azoospermia or severe oligospermia but could not achieve full suppression in all subjects even when high doses of D-P plus D- T were used. Full recovery of spermatogenesis should be achieved in. all subjects following cessation of drug administration. Any types of side effects even transient loss of libido and sexual potentia should not be occurred by the drug administration in actually all age groups of subjects who are treated. The maintenance doses should be confirmed at which the subjects remained consistently infertile during the drug administration without any drug resistant phenomenon.