선천 매독에 의한 치아 원기의 변화

Abstract

A histopathological study was made on two cases of congenital syphilis, with special emphasis on the changes of developing tooth germ and surrounding jaw bones. Both cases were conlirmed to be syphilis by serology and tissue Levaditi staining method. Both cases were deadborn fetuses. There was a quite remarkable degree of inflammatory changes in the developing teeth germ especially in dental papillae and perifollicular areas. Microabscess formation with prominent neutrophilic inliltration was characteristic feature together with lymphoplasmacytic inliltration and Iibrosis. Highly vascular tissue showed more severe involvement than less vascular ones. There was a delinite disturbance of amelogenesis and dentinogenesis during the process of tooth development, as those structures were directly involved by the inflammatory changes in which numerous spirochetes were recovered by Levaditi stains. The spirochetes were found in the ameloblast layer, stellate reticulum of enamel epithelium, odontoblast layer and predentin layer. The degree of involvement or severity of inflammatory reaction was more prominent in earlier-developing tooth, i.e., incisors among deciduous teeth and Iirst molar among permanent teeth, and was more evident in the upper jaw as it was compared to the lower jaw•