백혈병세포의 에너지대사

Abstract

The metabolism of the leukemic cells taken from peripheral blood of patients with acute and chronic lymphocytic leukemia and granulocytic leukemia was determined manometrically with the Warburg method. Results can be summarized as follows. 1. Leukocytes taken from patients having acute and chronic Iymphytic leukemia are characterized by low aerobic glycolysis and low QAo'/QO, ratio. Leukemic lymphocytes do not exhibit the so-called "tumor-metabolism". 2. Granulocytic cells have high glycolytic rate and high QAo'/QO, ratio and show incomplete Pasteur effect. 3. Both leukemic lymphocytes and granulocytes have the capacity for high glycolytic rates under anaerobic conditions. 4. It seems that the metabolism of normal human leukocyte is qualitatively similar to that of leukemic counterparts. 5. It appears that both mature cells and blast forms have same metabolic characteristics. 6. It is considered that to make conclusions regarding the neoplastic nature of leukemia on the basis of their tumor-metabolism is improper.