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급성 일산화탄소 중독시의 소장운동과 흡수기능
Intestinal Motility and Absorption in Acute Carbon Monoxide Poisoning

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Authors
이방제신동훈
Issue Date
1974-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.15 No.2, pp. 95-105
Abstract
Adult rabbits were exposed to carbon monoxide.
1.000ppm or 3.000ppm. and the motility of the ileum
and the absorptive function were studied.
The motility was expressed in terms of the frequency
of the peristalsis and the amplitude of the
peristaltic wave. A test solution was put in the
intestinal loop made in the ileum, and the decreases
in the components of the solution were measured in
the samples taken after 30 minutes period. The test
solution contained urea and sodium ion which were
subjected to passive or active transport, respectively.
As a marker substance for the volume measurement,
polyethylene glycol was added in the solution, too.
One hour after the insertion of the tracheal canule,
the first trial was performed, that was the test
solution was placed in the loop, leaving it for 30
minutes. after which the final sample was obtained
for the purpose of analysis. It was the experiment
of period I.
Following the period I. the animal was exposed
to the carbon monoxide for 90minutes except in the
control group. after which same trial was performed
as in the period I. This period of inhalation of
carbon monoxide was denoted as the period n. In
the period ill, carbon monoxide containing gas was replaced by fresh air. otherwise the experimental
procedure was same as in period I or H. The
control experiments were composed of the same
procedure as above. except using carbon monoxide
in the period H. They followed the time schedule
of the experiments in which carbon monoxide was
used.
In the control experiments. deteriorations in the
physiological parameters including the intestinal
function were noticed as the time elapsed even in
the absence of carbon monoxide. Animals faced
long standing adverse conditions other than
carbon monoxide inhalation would suffer from the
impairment of functions. Therefore, the results
obtained in the experimental groups were compared
with those of the same period of the control group.
The results obtained were as follows;
1. The oxygen content of the arterial blood subjected
to 1. OOOppm or 3.000ppm carbon monoxide
was 10.6 vol. % or 8.8 vol. %. respectively. They
rose to 14.8 vol. % or 13.5 vol. % when the inhaled
gas was replaced by fresh air.
2. Although slight degree of slowing in the heart
rate and drop in the mean arterial blood pressure
were revealed, there was little consistent influence
upon the circulatory function.
3. Slight increase in the frequency of the peristaltic
waves was noticed when the noxious gas was
given. The tension developed in the longitudinal
direction of the small intestine was markedly dropped
by the 1. 000 ppm of carbon monoxide. However.
occasionally strong peristaltic waves predominated
in the cases of 3.000ppm.
4. The absorption of sodium ion was impaired by
the exposure to carbon monoxide. and the recovery
was not completed in the course of fresh air inhalation
up to 2 hours. On the contrary. the absorption
of urea suffered little influences.
5. The volume of the intestinal loop increased in
.the case of high concentration of carbon monoxide.
and it seemed to be related to the deterioration of
the active absorption process.
6. The results were reviewed from the point of
view of clinical signs. such as diarrhea. encountered
not rarely in carbon monoxide poisoning.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/7281
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 15 No.2 (1974)
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