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Changes in Histopathological and Serological Findings of the Liver after Treatment in Rabbit Clonorchiasis
DC Field | Value | Language |
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dc.contributor.author | Hong, Sung-Tae | - |
dc.contributor.author | Huh, Sun | - |
dc.contributor.author | Kho, Weon-Gyu | - |
dc.contributor.author | Yu, Jae-Ran | - |
dc.contributor.author | Chai, Jong-Yil | - |
dc.contributor.author | Kim, Eui-Chong | - |
dc.contributor.author | Lee, Soon-Hyung | - |
dc.date.accessioned | 2009-08-20T05:14:53Z | - |
dc.date.available | 2009-08-20T05:14:53Z | - |
dc.date.issued | 1990-06 | - |
dc.identifier.citation | Seoul J Med, Vol.31 No.2, pp. 117-127 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7310 | - |
dc.description.abstract | In order to elucidate the recovery course and the residual change of clonorchiasis
after praziquantel treatment, the changing pattem of histopathological findings of the liver, along with the serological, biochemical and hematological parameters, were evaluated in experimental rabbit clonorchiasis. Twenty rabbits were infected each with 300 metacercariae of Clonorchis sinensis and treated with praziquantel 200 mg/kg 14 weeks after infection. Until one year after infection, a Widening of the bile ducts, proliferation of biliary epithelium, and periductal fibrosis were observed in the liver, although the lesions became much milder than those of the untreated rabbits. The levels of anti-e. sinensis IgG antibody in the sera by EUSA decreased continuously after treatment. Biochemical items and hematological parameters showed no consistent changing pattem after infection or after treatment. It can be suggested that the histopathological lesions of rabbit cionorchlais, i.e., duct dilatation, hyperplasia of biliary epithelium and periductal fibrosis, may be hardly reversible. However, the level of circulating specific IgG antibody decreased significantly according to the healing process of inflammation. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Clonorchis sinensis | - |
dc.subject | Rabbit | - |
dc.subject | Praziquantel | - |
dc.subject | Histopathology | - |
dc.subject | ELISA | - |
dc.subject | Biochemistry | - |
dc.subject | Hematology | - |
dc.title | Changes in Histopathological and Serological Findings of the Liver after Treatment in Rabbit Clonorchiasis | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 홍성태 | - |
dc.contributor.AlternativeAuthor | 허선 | - |
dc.contributor.AlternativeAuthor | 고원규 | - |
dc.contributor.AlternativeAuthor | 유재란 | - |
dc.contributor.AlternativeAuthor | 채종일 | - |
dc.contributor.AlternativeAuthor | 김의종 | - |
dc.contributor.AlternativeAuthor | 이순형 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 127 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 117-127 | - |
dc.citation.startpage | 117 | - |
dc.citation.volume | 31 | - |
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