S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 31 No.3 (1990)
Detection of Human Papillomavirus DNA in Squamous Papilloma of the Larynx by In Situ Hybridization
In Situ Hybridization을 이용한 후두 유두종 조직내 Human Papillomavirus DNA의 검색
- Park, Kyoung Chan; Park, Hyang Joon; Seo, Jeong Wook; Kim, Kwang Hyun; Lee, Yoo Shin
- Issue Date
- Seoul J Med, Vol.31 No.3, pp. 201-205
- ln situ hybridization using digoxigenin labeled HPV(human papillornaviruses)
probes was tried in order to detect the presence of HPV DNA in 27 cases of single
and multiple laryngeal papilloma. There were HPV6/11 DNA signals in 17 out of 22
cases of multiple laryngeal papilloma and in all five cases of single laryngeal papilloma.
The specific signals were seen focally in the nuclei of superficial epithelial cells. None
of the cases was positive for HPVI6/18. There was no cross hybridization between
HPV6/11 and HPV16/18 under the stringent conditions used in these experiments. So
it could be said that HPV6/11-related sequences were found in laryngeal papillomas.