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The Significance of DNA Ploidy by Flow Cytometric Measurement in Pancreatic Cancer

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Authors
Lee, Kuhn Uk; Woo, Young Min; Kim, Woo Ho; Kim, Yong Il
Issue Date
1994-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.35 No.2, pp. 83-90
Keywords
Flow cytometryPancreatic cancerPloidy
Abstract
The cellular DNA content of pancreatic cancer using formalin-fixed,
paraffin-embedded specimens from 37 patients whose disease had been treated with
surgical resection was determined by flow cytometry. Ploidy and cell cycle parameters
were analysed and correlated with clinical and pathologic findings. There were 24 (64.
9%) diploid and 13 non-diploid pancreatic cancers. The median survival of the patients
with diploid tumor was 14 months and that of the patients with non-diploid tumor was
8 months, but the difference did not have statistical significance (p=O. 078). And other
cytometric parameters such as Gl phase fraction (p=O. 84), S phase fraction (0. 076),
G2M phase fraction (p=O. 72), and proliferative index (p=O. 81) did not show any significant
prognostic value. The patients with stage I (n=15) had 27 months of median
survival, the patients with stage II (n=8) 7 months of median survival, the patients with
stage III (n> 15) 9 months of median survival. The differences of survival by stage were
the most significant among the parameters which were studied (p=O. 0003). The group
which had lymph node metastasis (n> 11) showed 7 months of median survival and the
group with negative lymph node (n=26) 12 months. The difference was also significant
(p=O. 046). The other clinical parameters such as sex, the size of tumor, and the location
of tumor did not have any influence on the prognosis of the pancreatic cancer
patients in this study. Multivariate analysis by Weibull's model was used for prediction
of survival time. Diploid versus non-diploid DNA content changed to less significant
factor after adjustment for stage and lymph node. But the stage of the tumor remained
a highly significant prognostic factor even after adjustment for ploidy and lymph node
status.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/7335
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 35 No.2 (1994)
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