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The Pathogenetic Role of Reactive Oxygen Species in Aminonucleoside Nephrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheong, Hae Il | - |
dc.contributor.author | Choi, Yong | - |
dc.contributor.author | Ko, Kwang Wook | - |
dc.contributor.author | Shin, Mi Ja | - |
dc.contributor.author | Kim, Myung-suk | - |
dc.date.accessioned | 2009-08-20T05:33:17Z | - |
dc.date.available | 2009-08-20T05:33:17Z | - |
dc.date.issued | 1994-06 | - |
dc.identifier.citation | Seoul J Med, Vol.35 No.2, pp. 105-111 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7338 | - |
dc.description.abstract | We studied the pathogenetic role of reactive oxygen species (ROS) in
rats with puromycin aminonucleoside nephrosis (PAN). Heavy albuminuria with markedly decreased density of the anionic sites (AS) on glomerular basement membrane (GBM) (2. 6 ± O. 98 compared to 20. 0 ± 1. 61 AS/l,OOOnm GBM in control) developed 7 days after PA injection. The malondialdehyde (MDA) levels in kidney homogenates increased gradually (1. 16 ± O. 18 at day -1 to 1. 97 ± O. 23/g protein at day 5). While catalase or dimethyl sulfoxide, administered with PA, did not affect the course of PAN. superoxide dismutase and allopurinol reduced proteinuria and decreased loss of the AS (11. 7 ± 2. 80 and 13, 7 ± 1. 27 AS/l.000nm GBM, reo spectively) at day 7. These findings suggest that proteinuria in PAN results from the loss of GBM AS. in which ROS generated by xanthine oxidase system plays an import. ant role. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Puromycin aminonucleoside nephrosis | - |
dc.subject | Anionic site | - |
dc.subject | Reactive oxygen species | - |
dc.subject | Xanthine oxidase | - |
dc.subject | Malondialdehyde | - |
dc.title | The Pathogenetic Role of Reactive Oxygen Species in Aminonucleoside Nephrosis | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 정해일 | - |
dc.contributor.AlternativeAuthor | 최용 | - |
dc.contributor.AlternativeAuthor | 고광욱 | - |
dc.contributor.AlternativeAuthor | 신미자 | - |
dc.contributor.AlternativeAuthor | 김명석 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 111 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 105-111 | - |
dc.citation.startpage | 105 | - |
dc.citation.volume | 35 | - |
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