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High CD99 Expression in Memory T and B Cells in Reactive Lymph Nodes

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Authors
Park, Cheol Keun; Shin, Young Kee; Kim, Tae Jin; Park, Seong Hoe; Ahn, Geung Hwan
Issue Date
1999
Publisher
The Korean Academy of Medical Sciences
Citation
J Korean Med Sci 1999;14(6):600-6
Keywords
ImmunohistochemistryLymphocyte transformationMemory
Abstract
We investigated the expression of CD99 in 35 hyperplastic perigastric lymph nodes, which were resected for gastric carcinoma or chronic peptic ulcer. Essentially, all lymphocytes in lymph nodes expressed CD99, but there were two populations with respect to the intensity of CD99 expression--CD99high and CD99low cells. We showed CD99high cells were distributed in paracortical and medullary cords by immunohistochemical study while germinal center cells were CD99low. Using three-color flow cytometric analysis with CD3, CD4, CD8, CD19, CD23, CD45RA, CD45RO, CD69, CD138, IgM, IgD, and IgG, most of CD99high cells were shown to be activated/memory T cells. CD4+CD45RO+ T cells were the subset revealing the highest intensity of CD99 expression while CD4+CD45RA+ T cells were CD99low. Among B cells, IgG+ B cells revealed a higher level of CD99 molecules than IgM+ B cells. These results suggest that CD99 is one of activation-related molecules which are upregulated in recently activated lymphocytes.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/73404
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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