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Iridoid 화합물이 창상 치유에 미치는 영향
The Effects of Iridoid Compounds on Wound Healing

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Authors
이승우; 고홍섭; 이상구
Issue Date
1999
Publisher
대한안면통증구강내과학회
Citation
대한구강내과학회지, 24(2) : 137-143, 1999
Keywords
iridoid compoundswound healingaucubin
Abstract
Aucubin, the natural product, which is isolated from Aucuba japoniaa, has a variety of pharmacological effects such as liver-protective function, inhibition of liver RNA and protein biosynthesis, hypotensive activity and antimicrobial effect, etc. This study was performed to investigate the effects of iridoid compounds on wound
healing. The author prepared 0.1% aucubin solution and 0.1% aucubin ointment as an active form, aucubigenin to which aucubin was converted by β-glucosidase. Artificial surgical wound was made on either lcm lateral
side of the dorsal midline along the axis of spine of Sprague-Dawley rats under sterile technicpe. Application of 0.1% aucubin solution or 0.1% aucubin ointment to surgical wound was done daily. Light microscopic examination was performed on the postsurgical 3 days, 5 days, and 9 days. The 0.1% aucubin solution group epithelialized earlier than the control group and the fibrosis of granulation tissue of both aucubin groups were more prominent than the control group. Collectively, this study suggests the possibility of aucubin as a topical agent. Further research should be performed on the mechanism of aucubin on wound healing and proper formulation for effective topical agents.
ISSN
1225-0627
Language
Korean
URI
https://hdl.handle.net/10371/73406
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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