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[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kBB in phorbol ester-stimulated mouse skin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sue Ok | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Park, Jin-Hong | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Kim, Tae-Yoon | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2011-06-08T03:29:59Z | - |
dc.date.available | 2011-06-08T03:29:59Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Oncogene, 24, 2558–2567 | en |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73409 | - |
dc.description.abstract | [6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. The present study was aimed at unraveling the molecular mechanisms underlying previously reported antitumor promoting effects of [6]-gingerol in mouse skin in vivo. One of the well-recognized molecular targets for chemoprevention is cyclooxygenase-2 (COX-2) that is abnormally upregulated in many premalignant and malignant tissues and cells. In our present study, topical application of [6]-gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Since the transcription factor nuclear factor-kappaB (NF-B) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-B. Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-B through suppression of IB degradation and p65 nuclear translocation. Phosphorylation of both IB and p65 was substantially blocked by [6]-gingerol. In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-B. Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin. The p38 MAP kinase inhibitor SB203580 attenuated NF-B activation and subsequent COX-2 induction in TPA-treated mouse skin. Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-B signaling pathway. | en |
dc.description.sponsorship | This work was supported by the National Research Laboratory Fund (allocated to Y-J Surh) from the Ministry of Science
and Technology, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | chemoprevention | en |
dc.subject | cyclooxygenase-2 | en |
dc.subject | [6]-gingerol | en |
dc.subject | p38 MAPK | en |
dc.subject | NF-kB | en |
dc.subject | mouse skin | en |
dc.title | [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kBB in phorbol ester-stimulated mouse skin | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김수옥 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 박진홍 | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.contributor.AlternativeAuthor | 깈태윤 | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
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