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Clinical Significance of CD99 Down-Regulation in Gastric Adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Hyun | - |
dc.contributor.author | Kim, Seok-Hyung | - |
dc.contributor.author | Li-Hui Wang | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Kim, Young Chul | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Park, Tae Sung | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Shin, Young Kee | - |
dc.date.accessioned | 2011-06-14T09:45:44Z | - |
dc.date.available | 2011-06-14T09:45:44Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | Clin Cancer Res; Vol.13(9); pp.2584-2591 | en |
dc.identifier.issn | 1557-3265 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73425 | - |
dc.description.abstract | Purpose: CD99 is a cell adhesion molecule associated with human tumors. The aim of the present study was to characterize its role in the development and progression of human gastric adenocarcinoma.
Experimental Design: The expression of CD99 was investigated in 283 gastric adenocarcinomas and related lesions and 9 gastric carcinoma cell lines. We also analyzed the methylation status of CD99 gene by using methylation-specific PCR and examined loss of heterozygosity (LOH) of this gene locus by using an intragenic marker. Moreover, we assessed whether SP1, a positive transcription factor for CD99, is expressed in these samples. Results: We found that the decreased expression of CD99 was strongly associated with poor survival and unfavorable clinicopathologic variables. Promoter region methylation (15 of 89, 16.9%) and LOH (21 of 74, 28.4%) were observed and significantly associated with CD99 down-regulation (P < 0.05). In addition, most of the gastric adenocarcinoma cases with CD99 down-regulation had reduced expression of SP1 (47 of 103, 45.6%; P < 0.01). This relationship between CD99 and SP1 was consolidated by using SP1 small interfering RNA transfection experiment and CD99 promoter luciferase assay. Furthermore, we showed that CD99 down-regulation was associated with proliferation and migration in gastric carcinoma cell line. Conclusion: These observations suggest that CD99 down-regulation is a critical event in the progression of gastric adenocarcinoma, and CD99 promoter methylation, CD99 LOH, and SP1 down-regulation were responsible for the down-regulation of CD99. | en |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | en |
dc.title | Clinical Significance of CD99 Down-Regulation in Gastric Adenocarcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정현 | - |
dc.contributor.AlternativeAuthor | 김석형 | - |
dc.contributor.AlternativeAuthor | 최윤라 | - |
dc.contributor.AlternativeAuthor | 김영철 | - |
dc.contributor.AlternativeAuthor | 김진희 | - |
dc.contributor.AlternativeAuthor | 박태성 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-06-1785 | - |
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