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Fetal Myoepithelial Cells of Submandibular Glands and Modified Myoepithelial Cells in Pleomorphic Adenoma : Immunohistochemistry and Ultrastructure

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dc.contributor.authorLee, Suk Keun-
dc.contributor.authorChi, Je Geun-
dc.contributor.authorMori, Masahiko-
dc.date.accessioned2009-08-20T05:35:06Z-
dc.date.available2009-08-20T05:35:06Z-
dc.date.issued1994-09-
dc.identifier.citationSeoul J Med, Vol.35 No.3, pp. 183-194-
dc.identifier.issn0582-6802-
dc.identifier.urihttp://hdl.handle.net/10371/7346-
dc.description.abstractTo elucidate the divergent expression of tissue markers for myoepithelial
cells (MECs) of submandibular glands. fetal submandibular glands (n 1(0). adult
submandibular glands (n 10) and pleomorphic adenoma (n 20) are examined
for cytokeratin 14(CK-14), vimentin, and a-smooth muscle actin(-SMA) by double
immunohistochemical methods. In addition fetal submandibular glands (n 20) and
pleomorphic adenoma ( n 3) are studied ultrastructurally to correlate with the immunohistochemical
findings. The polyhedral MECs found in the early intermediate developmental
stage (EIDS, 19-24 \U!eks) of fetal submandibular gland showed strong
CK-14 positivity, \U!ak a-SMA positivity. and occasional vimentin positivity. These
polyhedral MECs matured into \U!dge shaped, spindle or dendritic MECs. A large
number of dendritic MECs seen in the late developmental stage (LOS, 33·40 weeks)
showed a mild CK-14 positivity, strong a -SMApositivity, and negative vimentin. The
CK-14 was also expressed strongly for some basal cells of the excretory ducts and
rarely of striated ducts. while these ductal basal cells were negative for a -SMAand
vimentin. Electron microscopic examination of fetal submandibular glands disclosed abundant
intermediate filaments in the polyhedral MECs during the Ems, The intermediate
filaments gradually decreased in amount as MECs matured into dendritic
MECs in the LOS, and the dendritic MECs became filled with myofibrils. In pleomorphic
adenomas the plasmacytoid or modified MECs usually seen in periductal portions
showed coexpression of CK-14 a -SMAand vimentin a -SMAin double imrnunostaining.
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dc.language.isoen-
dc.publisherSeoul National University College of Medicine-
dc.subjectCytokeratin 14-
dc.subjectVimentin-
dc.subjectα-Smooth muscle actin-
dc.subjectMyoepithelial cell-
dc.subjectFetus-
dc.subjectAdult-
dc.subjectHuman-
dc.subjectSalivary gland-
dc.subjectPleomorphic adenoma-
dc.titleFetal Myoepithelial Cells of Submandibular Glands and Modified Myoepithelial Cells in Pleomorphic Adenoma : Immunohistochemistry and Ultrastructure-
dc.typeSNU Journal-
dc.contributor.AlternativeAuthor이석근-
dc.contributor.AlternativeAuthor지제근-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
dc.citation.endpage194-
dc.citation.number3-
dc.citation.pages183-194-
dc.citation.startpage183-
dc.citation.volume35-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 35 No.3 (1994)
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