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An Immunohistochemical Study of the Expression of Adhesion Molecules in Gallbladder Lesions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Xuan, Yan Hua | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Chae, Seoung Wan | - |
dc.contributor.author | Kook, Myeong Cherl | - |
dc.contributor.author | Sung, Ro Hyun | - |
dc.contributor.author | Youn, Sei Jin | - |
dc.contributor.author | Choi, Jae Woon | - |
dc.contributor.author | Kim, Seok Hyung | - |
dc.date.accessioned | 2011-07-14T04:02:00Z | - |
dc.date.available | 2011-07-14T04:02:00Z | - |
dc.date.issued | 2004-05 | - |
dc.identifier.citation | J Histochem Cytochem; Vol.52, No.5; pp.591–601 | en |
dc.identifier.issn | 1551-5044(Online) | - |
dc.identifier.issn | 0022-1554(Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/73477 | - |
dc.description.abstract | We investigated the expression of 10 adhesion molecules (α-catenin, β-cate-nin, γ-catenin, CD44, CD44v6, ICAM-1, CD56, CEA, E-cadherin, and CD99) in 46 gallbladder carcinomas, 14 adenomas, 15 low-grade dysplasias, nine intestinal metaplasias, and 20 samples of normal gallbladder epithelium by immunohistochemistry. The expression of adhesion molecules was altered in gallbladder carcinomas and adenomas. In gallbladder carcinomas, increased expression of ICAM-1, CEA, and CD44v6 was observed, together with decreased expression of α/β/γ-catenin and CD99. In adenomas, aberrant expression of CD44v6 and CD56, as well as reduced expression of α/β/γ- and E-cadherins, was noted. Expression of α/β/γ-catenin was reduced in low-grade dysplasia, whereas there was no change in the expression of these adhesion molecules in metaplasia. Expression of ICAM-1, CD99, E-cadherin, and CD56 was correlated with clinical stage. In addition a correlation was noted between expression of ICAM-1 and E-cadherin and lymph node metastasis (p<0.05). These results suggest that altered expression of these adhesion molecules is involved in the progression and metastasis of gallbladder carcinomas. | en |
dc.language.iso | en | en |
dc.publisher | Histochemical Society | en |
dc.subject | gallbladder | en |
dc.subject | catenin | en |
dc.subject | CD44 | en |
dc.subject | CD44v6 | en |
dc.subject | ICAM-1 | en |
dc.subject | CD56 | en |
dc.subject | CEA | en |
dc.subject | E-cadherin | en |
dc.subject | CD99 | en |
dc.subject | immunohistochemistry | en |
dc.title | An Immunohistochemical Study of the Expression of Adhesion Molecules in Gallbladder Lesions | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최윤라 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 채성완 | - |
dc.contributor.AlternativeAuthor | 국명철 | - |
dc.contributor.AlternativeAuthor | 성노현 | - |
dc.contributor.AlternativeAuthor | 윤세진 | - |
dc.contributor.AlternativeAuthor | 최재운 | - |
dc.contributor.AlternativeAuthor | 김석형 | - |
dc.identifier.doi | 10.1177/002215540405200504 | - |
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