Browse

Solution Structure of the Cytoplasmic Domain of Human CD99 Type I

Cited 0 time in Web of Science Cited 0 time in Scopus
Issue Date
2004-08
Publisher
Springer Verlag
Citation
Mol. Cells; Vol.18(1); pp.24-29
Keywords
ApoptosisCircular DichroismhCD99cytoINMR Spectroscopy
Abstract
Human CD99, which is encoded by the mic2 gene, is a ubiquitous 32 kDa transmembrane protein. Its major cellular functions are related to homotypic cell adhesion, apoptosis, vesicular protein transport, and differentiation of thymocytes or T cells. Recent reports have suggested that expression of a splice variant of CD99 increases the invasiveness of human breast cancer cells. In order to determine the structural basis of CD99 function, we have initiated structural studies on the human CD99 Type I cytoplasmic domain (hCD99cytoI) using circular dichroism and multi-dimensional NMR spectroscopy. The solution structure of hCD99cytoI shows that it has a hairpin shape anchored by two flexible loops. Consequently, hCD99cytoI does not have any regular secondary structural element; however, the NMR and CD data indicate that it possesses an intrinsic helical nature.
ISSN
1016-8478
Language
English
URI
https://hdl.handle.net/10371/73480
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse