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LMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cells

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dc.contributor.authorLee, Im-Soon-
dc.contributor.authorShin, Young Kee-
dc.contributor.authorChung, Doo Hyun-
dc.contributor.authorPark, Seong Hoe-
dc.date.accessioned2011-07-22T06:01:54Z-
dc.date.available2011-07-22T06:01:54Z-
dc.date.issued2001-08-
dc.identifier.citationLeuk Lymphoma; Vol.42(4); pp.587-594en
dc.identifier.issn1042-8194-
dc.identifier.urihttps://hdl.handle.net/10371/73500-
dc.description.abstractHodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD). So far, several characteristics frequently seen in H-RS cells from different origins have been described, such as the high expression of Epstein-Barr virus latent membrane protein 1 (LMP1), the elevation of NF-kB activity, and the aberrant expression of molecules such as CD15, CD30, and CD99. Despite extensive studies on the nature of H-RS cells, the molecular mechanism by which H-RS cells are generated remained elusive. Recently, the forced down-regulation of CD99 was reported to induce typical H-RS phenotypes in vitro in a B cell line. Furthermore, it was revealed that LMP1 markedly reduces the CD99 expression at the transcriptional level. Since the presence of LMP1 is known to be associated with the H-RS cell formation, the data provide a possibility of linkage between LMP1 and HD via CD99, thus suggesting that, at least in part, the loss of CD99 may play a critical role in the pathogenic sequence to the formation of H-RS cells in HD. In this review, the role of CD99 in the generation of H-RS cells and its molecular mechanism will be suggested.en
dc.language.isoenen
dc.publisherInforma Healthcareen
dc.subjectCD99en
dc.subjectLMP1en
dc.subjectNF-kappaBen
dc.subjectH-RS cellsen
dc.subjecthodgkin's diseaseen
dc.titleLMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor이임순-
dc.contributor.AlternativeAuthor신영기-
dc.contributor.AlternativeAuthor정두현-
dc.contributor.AlternativeAuthor박성회-
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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