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LMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Im-Soon | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2011-07-22T06:01:54Z | - |
dc.date.available | 2011-07-22T06:01:54Z | - |
dc.date.issued | 2001-08 | - |
dc.identifier.citation | Leuk Lymphoma; Vol.42(4); pp.587-594 | en |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73500 | - |
dc.description.abstract | Hodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD). So far, several characteristics frequently seen in H-RS cells from different origins have been described, such as the high expression of Epstein-Barr virus latent membrane protein 1 (LMP1), the elevation of NF-kB activity, and the aberrant expression of molecules such as CD15, CD30, and CD99. Despite extensive studies on the nature of H-RS cells, the molecular mechanism by which H-RS cells are generated remained elusive. Recently, the forced down-regulation of CD99 was reported to induce typical H-RS phenotypes in vitro in a B cell line. Furthermore, it was revealed that LMP1 markedly reduces the CD99 expression at the transcriptional level. Since the presence of LMP1 is known to be associated with the H-RS cell formation, the data provide a possibility of linkage between LMP1 and HD via CD99, thus suggesting that, at least in part, the loss of CD99 may play a critical role in the pathogenic sequence to the formation of H-RS cells in HD. In this review, the role of CD99 in the generation of H-RS cells and its molecular mechanism will be suggested. | en |
dc.language.iso | en | en |
dc.publisher | Informa Healthcare | en |
dc.subject | CD99 | en |
dc.subject | LMP1 | en |
dc.subject | NF-kappaB | en |
dc.subject | H-RS cells | en |
dc.subject | hodgkin's disease | en |
dc.title | LMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이임순 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
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