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CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, Hae Won | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Lee, Im-Soon | - |
dc.contributor.author | Bae, Young Mee | - |
dc.contributor.author | Suh, Young Ho | - |
dc.contributor.author | Kim, Min Kyung | - |
dc.contributor.author | Kim, Tae Jin | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Park, Weon Seo | - |
dc.contributor.author | Park, Chan-Sik | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Ahn, Kwangseog | - |
dc.contributor.author | Kim, In Sun | - |
dc.contributor.author | Ko, Young Hyeh | - |
dc.contributor.author | Bang, Yung Jue | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2011-07-22T06:22:56Z | - |
dc.date.available | 2011-07-22T06:22:56Z | - |
dc.date.issued | 2001-01 | - |
dc.identifier.citation | J Immunol; Vol.166, No.2; pp.787–794 | en |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73501 | - |
dc.description.abstract | The down-regulation of surface expression of MHC class I molecules has recently been reported in the CD99-deficient lymphoblastoid B cell line displaying the characteristics of Hodgkins and Reed-Sternberg phenotype. Here, we demonstrate that the reduction of MHC class I molecules on the cell surface is primarily due to a defect in the transport from the Golgi complex to the plasma membrane. Loss of CD99 did not affect the steady-state expression levels of mRNA and protein of MHC class I molecules. In addition, the assembly of MHC class I molecules and the transport from the endoplasmic reticulum to the cis-Golgi occurred normally in the CD99-deficient cells, and no difference was detected between the CD99-deficient and the control cells in the pattern and degree of endocytosis. Instead, the CD99-deficient cells displayed the delayed transport of newly synthesized MHC class I molecules to the plasma membrane, thus causing accumulation of the molecules within the cells. The accumulated MHC class I molecules in the CD99-deficient cells were colocalized with α-mannosidase II and γ-adaptin in the Golgi compartment. These results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of MHC class I down-regulation for immune escape. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.title | CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 손해원 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 이임순 | - |
dc.contributor.AlternativeAuthor | 배영미 | - |
dc.contributor.AlternativeAuthor | 서영호 | - |
dc.contributor.AlternativeAuthor | 김민경 | - |
dc.contributor.AlternativeAuthor | 김태진 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 박원서 | - |
dc.contributor.AlternativeAuthor | 박찬식 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 안광석 | - |
dc.contributor.AlternativeAuthor | 김인선 | - |
dc.contributor.AlternativeAuthor | 고영혜 | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
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