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Reduced expression of CD99 and functional disturbance in anencephalic cortical thymocytes

Cited 10 time in Web of Science Cited 11 time in Scopus
Authors
Shin, Young Kee; Lee, Geon Kook; Kook, Myeong Cherl; Jung, Kyeong Cheon; Kim, Jung Ran; Song, Hyung Geun; Park, Seong Hoe; Chi, Je Geun
Issue Date
1999
Publisher
Springer
Citation
Virchows Arch; Vol.434, No.5; pp.443–449
Keywords
AnencephalyThymic hyperplasiaCD99ApoptosisAggregation
Abstract
In a significant proportion of cases, anencephaly is associated with thymic enlargement, suggesting a possibility that anencephalic fetuses have a functional
disturbance in thymocyte differentiation and development. In this report, we demonstrated that CD99 expression was consistently reduced in cortical thymocytes of
all anencephalic fetuses. In addition, the CD99-dependent aggregation of immature cortical thymocytes was almost completely impaired and apoptosis of thymocytes
was markedly reduced in several cases. These results are in agreement with previous findings that CD99 regulates the aggregation and apoptosis of various types of cells.
These data strongly suggest that functional disturbance of thymocytes and thymic hyperplasia are related to the reduced expression of CD99 molecule in anencephalic
fetuses.
ISSN
0945-6317
Language
English
URI
http://hdl.handle.net/10371/73516
DOI
https://doi.org/10.1007/s004280050364
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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