Immunohistochemical Characterization of the Human Sublingual Mucosa

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Choi, Youngnim; Hong, Sung Doo; Lee, Jongho; Cuburu, Nicolas; Saletti, Giulietta; Czerkinsky, Cecil

Issue Date
International Journal of Oral Biology
International Journal of Oral Biology 2009;34:131-5
sublingual mucosaimmunohistochemistrydendritic cellsmacrophagesT cellsB cellsTreg cells
The sublingual locus has recently received great attention
as a delivery site for various immunotherapies, including
those that induce allergen-specific tolerance, and for vaccines
that generate protective immunity. To further understand
the immune functions of the human sublingual mucosa, we
characterized the distribution of various immunocytes
therein by immunohistochemistry. We identified professional
antigen presenting cells (APCs), including Langerhans cells
(LCs) and macrophages. CD1a+ and langerin+ LCs were
further found to be distributed in the basal and supra-basal
layers of the epithelium, and macrophages were identified in
the lamina propria. HLA-DR+ cells were observed in both
the epithelium and the lamina propria, which mirrors the
tissue distribution of LCs and macrophages within these
tissues. CD3+, CD4+, and CD8+ T cells were found to be
distributed along the basal layer of the epithelium and also
in the lamina propria. Although B cells, plasma cells, and
Foxp3+ regulatory T cells (Tregs) were only occasionally
observed in the human sublingual mucosa in the absence of
inflammation, they did show enrichment at inflammatory
sites. Hence, we have further elucidated the immune cell
component distribution in human sublingual mucosa.
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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