Publications
Detailed Information
구강 편평세포암종에서 조직학적 침습양상과 분화도에 따른 Matrix Metalloproteinase-2와 -9의 발현 : Expression of Matrix Metalloproteinase-2 and -9 in Oral Squamous Cell Carcinomas in Relation to the Histologic Invasiveness and Cellular Differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍성두 | - |
dc.contributor.author | 홍삼표 | - |
dc.contributor.author | 김용식 | - |
dc.contributor.author | 이재일 | - |
dc.contributor.author | 임창윤 | - |
dc.date.accessioned | 2011-10-13T01:00:01Z | - |
dc.date.available | 2011-10-13T01:00:01Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Korean J Pathol 1999;33:243-50 | en |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74075 | - |
dc.description.abstract | A poor prognosis of oral squamous cell carcinoma (SCC) is partly due to the invasiveness and metastasis of the tumor. A key element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). This study was performed to determine the expression of MMP-2 and MMP-9 of oral SCCs with regard to the histologic invasiveness and differentiation in 5 normal oral mucosa and 36 oral SCCs. The histologic invasiveness of oral SCCs were classified into 4 grades. The differentiation of oral SCCs was divided into 3 grades. The streptavidin-biotin immunohisto-chemical staining, using MMP-2 and MMP-9 monoclonal antibodies, was performed to determine the expression of MMP-2 and MMP-9. The expression of MMP-2 was positive in 6 of 17 oral SCCs with weak invasiveness and was positive in 7 of 19 oral SCCs with strong invasiveness. The MMP-2 expression did not increase significantly with respect to the invasiveness of oral SCCs (p>0.05). The expression of MMP-9 was strongly positive in 6 out 17 SCCs with weak invasiveness and was strongly positive in 14 of 19 SCCs with strong invasiveness.
The MMP-9 expression increased significantly with respect to the invasiveness of oral SCCs; the stronger the expression, the stronger the invasiveness (p<0.05). The expression of MMP-9 was in 57.9% of well differentiated SCCs, 57.1% of moderately differentiated ones, and 33.3% of poorly differentiation SCCs. The expression of MMP-2 and MMP-9 did not increase significantly with respect to the histologic ifferentiation. We conclude that with respect to the invasiveness, the MMP-9 did not increase significantly in oral SCCs but the MMP-2 expression does not; and that with respect to the histologic differentiation, their expression do not increase significantly. These results suggest that MMP-9 can be used as a tool to evaluate the invasiveness of oral SCCs. | en |
dc.description.sponsorship | 본 연구는 1997년도 교육부 지원 기초의학 학술연구조성비의 지원으로 수행되었으며 지원에 감사를 드립니다. | en |
dc.language.iso | ko | en |
dc.publisher | 대한병리학회 | en |
dc.subject | Squamous cell carcinoma | en |
dc.subject | Invasiveness | en |
dc.subject | Differentiation | en |
dc.subject | MMP-2 | en |
dc.subject | MMP-9 | en |
dc.title | 구강 편평세포암종에서 조직학적 침습양상과 분화도에 따른 Matrix Metalloproteinase-2와 -9의 발현 | en |
dc.title.alternative | Expression of Matrix Metalloproteinase-2 and -9 in Oral Squamous Cell Carcinomas in Relation to the Histologic Invasiveness and Cellular Differentiation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | Hong, Seong-Doo | - |
dc.contributor.AlternativeAuthor | Hong, Sam-Pyo | - |
dc.contributor.AlternativeAuthor | Kim, Yong-Sik | - |
dc.contributor.AlternativeAuthor | Lee, Jae-Il | - |
dc.contributor.AlternativeAuthor | Lim, Chang-Yun | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.