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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans

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dc.contributor.authorJang, J. Y.-
dc.contributor.authorPark, E. K.-
dc.contributor.authorRyoo, H. M.-
dc.contributor.authorShin, H. I.-
dc.contributor.authorKim, T. H.-
dc.contributor.authorJang, J. S.-
dc.contributor.authorPark, H. S.-
dc.contributor.authorChoi, J. Y.-
dc.contributor.authorKwon, T. G.-
dc.date.accessioned2011-10-13T06:41:03Z-
dc.date.available2011-10-13T06:41:03Z-
dc.date.issued2010-11-
dc.identifier.citationJ Dent Res 89:1203-1207en
dc.identifier.issn0022-0345-
dc.identifier.urihttps://hdl.handle.net/10371/74109-
dc.description.abstractPrevious linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19∼197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05∼0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03∼13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism.en
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea
(NRF), funded by the Ministry of Education, Science and Technology (R13–2008–009–01003–0).
en
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.subjectMatrilin-1en
dc.subjectmandibular prognathismen
dc.subjectpolymorphismen
dc.subjectSNPen
dc.titlePolymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreansen
dc.typeArticleen
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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