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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, J. Y. | - |
dc.contributor.author | Park, E. K. | - |
dc.contributor.author | Ryoo, H. M. | - |
dc.contributor.author | Shin, H. I. | - |
dc.contributor.author | Kim, T. H. | - |
dc.contributor.author | Jang, J. S. | - |
dc.contributor.author | Park, H. S. | - |
dc.contributor.author | Choi, J. Y. | - |
dc.contributor.author | Kwon, T. G. | - |
dc.date.accessioned | 2011-10-13T06:41:03Z | - |
dc.date.available | 2011-10-13T06:41:03Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | J Dent Res 89:1203-1207 | en |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74109 | - |
dc.description.abstract | Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19∼197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05∼0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03∼13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism. | en |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea
(NRF), funded by the Ministry of Education, Science and Technology (R13–2008–009–01003–0). | en |
dc.language.iso | en | en |
dc.publisher | SAGE Publications | en |
dc.subject | Matrilin-1 | en |
dc.subject | mandibular prognathism | en |
dc.subject | polymorphism | en |
dc.subject | SNP | en |
dc.title | Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans | en |
dc.type | Article | en |
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