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Inhibition of L-Type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Chun Sung | - |
dc.contributor.author | Moon, In-Sung | - |
dc.contributor.author | Park, Ju-Hyun | - |
dc.contributor.author | Shin, Woo-Cheol | - |
dc.contributor.author | Chun, Hong Sung | - |
dc.contributor.author | Lee, Sook-Young | - |
dc.contributor.author | Kook, Joong-Ki | - |
dc.contributor.author | Kim, Heung-Joong | - |
dc.contributor.author | Park, Joo-Cheol | - |
dc.contributor.author | Endou, Hitoshi | - |
dc.contributor.author | Kanai, Yoshikatsu | - |
dc.contributor.author | Lee, Byung-Kwon | - |
dc.contributor.author | Kim, Do Kyung | - |
dc.date.accessioned | 2011-10-13T08:28:19Z | - |
dc.date.available | 2011-10-13T08:28:19Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | Biological and Pharmaceutical Bulletin 33,1117-1121 (2010) | en |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74120 | - |
dc.description.abstract | The purpose of this study was to examine the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of L-type amino acid transporters, on the cell growth suppression in KB human oral cancer cells and to study the roles of cell cycle regulatory factors in the BCH-induced growth inhibition. The effect of BCH on cell growth suppression and the influence of BCH to cell cycle regulatory factors in KB cell growth inhibition were examined using cell cycle analysis, immunoblotting and immunoprecipitation. The BCH treatment induced cell cycle arrest at G1 phase in KB cells. The expression of cyclin D3 was remarkably decreased by BCH treatment. The BCH inhibited the expression of cyclin-dependent protein kinase 6 (CDK6) in a time-dependent manner. In addition, the expression of CDK inhibitor p27 was increased by BCH treatment in KB cells, but not CDK inhibitors p21 and p15. These results suggest that, in KB cells, the inhibition of LAT1 by BCH causes cell cycle arrest at G1 phase by inhibiting cyclin D3-CDK6 complex whereas increasing expression of a CDK inhibitor p27. | en |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(KRF-2008-313-E00551). | en |
dc.language.iso | en | en |
dc.publisher | Pharmaceutical Society of Japan | en |
dc.subject | L-type amino acid transporter | en |
dc.subject | cancer cell | en |
dc.subject | cell cycle regulatory factor | en |
dc.subject | 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid | en |
dc.title | Inhibition of L-Type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김천성 | - |
dc.contributor.AlternativeAuthor | 문인성 | - |
dc.contributor.AlternativeAuthor | 박주현 | - |
dc.contributor.AlternativeAuthor | 신우철 | - |
dc.contributor.AlternativeAuthor | 천종성 | - |
dc.contributor.AlternativeAuthor | 이숙영 | - |
dc.contributor.AlternativeAuthor | 국중기 | - |
dc.contributor.AlternativeAuthor | 김흥중 | - |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.contributor.AlternativeAuthor | 이병권 | - |
dc.contributor.AlternativeAuthor | 김도경 | - |
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