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Evaluation of survivin as a prognostic marker in oral squamous cell carcinoma

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dc.contributor.authorKim, Yong-Hun-
dc.contributor.authorKim, Soung-Min-
dc.contributor.authorKim, Yu-Kyoung-
dc.contributor.authorHong, Sam-Pyo-
dc.contributor.authorKim, Myung-Jin-
dc.contributor.authorMyoung, Hoon-
dc.date.accessioned2011-10-14T02:06:31Z-
dc.date.available2011-10-14T02:06:31Z-
dc.date.issued2010-05-
dc.identifier.citationJ Oral Pathol Med 2010;39:368–375en
dc.identifier.issn0904-2512-
dc.identifier.urihttps://hdl.handle.net/10371/74137-
dc.description.abstractBackground: Poor prognosis of oral squamous cell carcinoma (OSCC) is partly attributed to the lack of significant tumor marker for accurate staging and prognostication. We have evaluated survivin, which is a member of the inhibitor of apoptosis family as a cancer marker associated with proliferation, angiogenesis, oral carcinogenesis, and OSCC patient survival, as we reported a prognostic significance of survivin expression in lymph node previously. Methods: To evaluate survivin expression in six OSCC cell lines, Western blotting was performed. Hamster oral carcinogenesis model was used to observe changes of survivin expression in oral carcinogenesis. Finally, we assessed the diagnostic and prognostic significance of survivin in a series of 38 primary OSCC through immunohistochemistry (CD31, PCNA) and Kaplan-Meier's test. Results: Survivin expression was detected in all OSCC cell lines at a varying level but not observed in normal gingival keratinocyte cells. In hamster model, survivin expression was observed from 8 weeks through 16 weeks and the intensity of expression became strong until 16 weeks. Clinicopathological analysis revealed a significant correlation between survivin expression and lymph node metastasis (P = 0.006) and proliferation (P < 0.001). However, there was no significant relationship with differentiation, micro vessel density, and cancer stage based on TNM. Survivin overexpression had a significant negative effect on survival of patients. Conclusions: These results demonstrate the significant relationship between survivin expression and oral carcinogenesis and aggressiveness of OSCC including survival rate of patient. Survivin therefore may be used as a significant cancer marker to gain prognostic information of OSCC.en
dc.description.sponsorshipThis research was supported by Basic Science Research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2009-0075293).en
dc.language.isoenen
dc.publisherJohn Wiley and Sonsen
dc.subjectoral squamous cell carcinomaen
dc.subjectprognostic markeren
dc.subjectsurvivinen
dc.titleEvaluation of survivin as a prognostic marker in oral squamous cell carcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor김용훈-
dc.contributor.AlternativeAuthor김성민-
dc.contributor.AlternativeAuthor김유경-
dc.contributor.AlternativeAuthor홍삼표-
dc.contributor.AlternativeAuthor김명진-
dc.contributor.AlternativeAuthor명훈-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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