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The transcription factor snail regulates osteogenic differentiation by repressing Runx2 expression

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Authors
Park, Su Jin; Jung, Seung-Hyun; Jogeswar, Gadi; Ryoo, Hyun-Mo; Yook, Jong In; Choi, Han Seok; Rhee, Yumie; Kim, Cheol-Hee; Lim, Sung-Kil
Issue Date
2010-06
Publisher
Elsevier
Citation
Bone 2010;46:1498-1507
Keywords
SnailRunx2E-boxOsteogenic differentiation
Abstract
Osteoblasts originate from mesenchymal stem cells by the coordinated activities of different signaling pathways that regulate the expression of osteoblast-specific genes. Runt-related transcription factor 2 (Runx2) is the master transcription factor for osteoblast differentiation. Despite the importance of Runx2 in the developing skeleton, how Runx2 expression is regulated remains a pivotal question. Snail, a zinc finger transcription factor, is essential for triggering epithelial-to-mesenchymal transitions (EMTs) during embryonic development and tumor progression. Here, we report that Runx2 expression is significantly up- or down-regulated relative to Snail expression. We demonstrate that Snail binds to the Runx2 promoter and that repression of Runx2 transcription by Snail is dependent on specific E-box sequence within the promoter. With antisense morpholino oligonucleotide (MO)-mediated knockdown of Snail expression in zebrafish, we observed alterations in osteogenic potential. These results indicate that Snail plays a crucial role in osteogenic differentiation by acting as a direct Runx2 repressor.
ISSN
8756-3282
Language
English
URI
https://hdl.handle.net/10371/74173
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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