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Osteoconductive and degradable electrospun nonwoven poly(ε- caprolactone)/CaO-SiO2 gel composite fabric
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seol, Yang-Jo | - |
dc.contributor.author | Kim, Kyoung-Hwa | - |
dc.contributor.author | Kim, In Ae | - |
dc.contributor.author | Rhee, Sang-Hoon | - |
dc.date.accessioned | 2011-10-17 | - |
dc.date.available | 2011-10-17 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | J Biomed Mater Res Part A 2010;94A:649–659 | en |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74178 | - |
dc.description.abstract | A nonwoven ceramic/polymer composite fabric composed of randomly mixed bioactive and fast degradable CaO-SiO2 gel fibers and biodegradable poly(ε-caprolactone) (PCL) fibers is prepared with a simultaneous electrospinning method for potential use as bone grafting materials. A 17% PCL solution is prepared using 1,1,3,3-hexafluoro-2-propanol as the solvent, whereas the CaO-SiO2 gel solution is prepared via a condensation reaction following the hydrolysis of tetraethyl orthosilicate. PCL and CaO-SiO 2 gel solutions are spun simultaneously with two separate nozzles. As controls, pure PCL and CaO-SiO2 gel nonwoven fabrics are also made by the same methods. The three nonwoven fabrics were exposed to simulated body fluid for 1 week and resulted in the deposition of a layer of apatite crystals on the surfaces of both the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics, but not on the PCL fabric. A tensile strength test showed that the fracture behavior of the CaO-SiO2 gel fabric was brittle, that of the PCL fabric was ductile-tough, and that of the PCL/CaO-SiO 2 gel composite fabric was intermediate between that of the CaO-SiO2 gel and PCL fabrics. Our in vivo tests showed that the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics had good osteoconductivity and fast degradation rates in calvarial defects of New Zealand white rabbits within 4 weeks, in contrast to the pure PCL fabric. Together, these results suggest that the composite fabric composed of PCL and CaO-SiO2 gel fibers must have a great potential for use in applications such as bone grafting because of its good osteoconductivity and adequate mechanical properties. | en |
dc.description.sponsorship | Contract grant sponsor: Korea Science and Engineering Foundation; contract grant number: R01-2005-000-10375-0
Contract grant sponsor: The Nano Bio R&D Program of the Korea Science and Engineering Foundation; contract grant number: M0528010001-06N2801-00110 | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | poly(ε-caprolactone) | en |
dc.subject | CaO-SiO2 gel | en |
dc.subject | electrospinning | en |
dc.subject | composite | en |
dc.subject | degradability | en |
dc.subject | osteoconductivity | en |
dc.title | Osteoconductive and degradable electrospun nonwoven poly(ε- caprolactone)/CaO-SiO2 gel composite fabric | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 설양조 | - |
dc.contributor.AlternativeAuthor | 김경화 | - |
dc.contributor.AlternativeAuthor | 김인애 | - |
dc.contributor.AlternativeAuthor | 이상훈 | - |
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