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Tissue expression of manganese superoxide dismutase is a candidate prognostic marker for glioblastoma

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dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorJung, Ji Hye-
dc.contributor.authorMoon, Min Jeong-
dc.contributor.authorKim, Young-Yim-
dc.contributor.authorKim, Jin Hyun-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Chae-Yong-
dc.contributor.authorPaek, Sun Ha-
dc.contributor.authorKim, Dong Gyu-
dc.contributor.authorJung, Hee-Won-
dc.contributor.authorCho, Byung-Kyu-
dc.date.accessioned2011-10-17T04:26:03Z-
dc.date.available2011-10-17T04:26:03Z-
dc.date.issued2009-07-
dc.identifier.citationOncology 2009;77:178-181en
dc.identifier.issn0030-2414-
dc.identifier.urihttps://hdl.handle.net/10371/74201-
dc.description.abstractBackground: Characterization of a rare subgroup of glioblastoma
patients who survive for more than 3 years (longterm
survival glioblastoma, LTSGBL, patients) may be helpful
to identify prognostic factors. Materials and Methods: A
molecular-profiling proteomic approach using two-dimensional
gel electrophoresis (2-DE) and matrix-assisted la ser
desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS) were used to identify prognostic factors associated
with glioblastoma by comparing frozen tumor tissue
from LTSGBL patients with matched samples from shortterm
survival glioblastoma (STSGBL) patients. Western blot
(WB) analysis, reverse-transcriptase polymerase chain reaction
(RT-PCR) and immmunohistochemical (IHC) staining
were used for confirmation. Results: Among most candidate
spots identified by 2-DE, lack of overexpression of manganese
superoxide dismutase (MnSOD) in LTSGBL samples was
consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor
tissue is a candidate marker for the prognosis of glioblastoma
patients.
en
dc.description.sponsorshipThis study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (0520300) and the SNUH Research Fund (04-2007-100).en
dc.language.isoenen
dc.publisherKargeren
dc.subjectProteomicsen
dc.subjectLong-term survivalen
dc.subjectGlioblastomaen
dc.subjectPrognostic factoren
dc.subjectManganese superoxide dismutaseen
dc.titleTissue expression of manganese superoxide dismutase is a candidate prognostic marker for glioblastomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor정지혜-
dc.contributor.AlternativeAuthor문민정-
dc.contributor.AlternativeAuthor김영임-
dc.contributor.AlternativeAuthor김진현-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김채용-
dc.contributor.AlternativeAuthor백선하-
dc.contributor.AlternativeAuthor김동규-
dc.contributor.AlternativeAuthor정희원-
dc.contributor.AlternativeAuthor조병규-
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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