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Tissue expression of manganese superoxide dismutase is a candidate prognostic marker for glioblastoma
DC Field | Value | Language |
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dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Jung, Ji Hye | - |
dc.contributor.author | Moon, Min Jeong | - |
dc.contributor.author | Kim, Young-Yim | - |
dc.contributor.author | Kim, Jin Hyun | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.contributor.author | Cho, Byung-Kyu | - |
dc.date.accessioned | 2011-10-17T04:26:03Z | - |
dc.date.available | 2011-10-17T04:26:03Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.citation | Oncology 2009;77:178-181 | en |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74201 | - |
dc.description.abstract | Background: Characterization of a rare subgroup of glioblastoma
patients who survive for more than 3 years (longterm survival glioblastoma, LTSGBL, patients) may be helpful to identify prognostic factors. Materials and Methods: A molecular-profiling proteomic approach using two-dimensional gel electrophoresis (2-DE) and matrix-assisted la ser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to identify prognostic factors associated with glioblastoma by comparing frozen tumor tissue from LTSGBL patients with matched samples from shortterm survival glioblastoma (STSGBL) patients. Western blot (WB) analysis, reverse-transcriptase polymerase chain reaction (RT-PCR) and immmunohistochemical (IHC) staining were used for confirmation. Results: Among most candidate spots identified by 2-DE, lack of overexpression of manganese superoxide dismutase (MnSOD) in LTSGBL samples was consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor tissue is a candidate marker for the prognosis of glioblastoma patients. | en |
dc.description.sponsorship | This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (0520300) and the SNUH Research Fund (04-2007-100). | en |
dc.language.iso | en | en |
dc.publisher | Karger | en |
dc.subject | Proteomics | en |
dc.subject | Long-term survival | en |
dc.subject | Glioblastoma | en |
dc.subject | Prognostic factor | en |
dc.subject | Manganese superoxide dismutase | en |
dc.title | Tissue expression of manganese superoxide dismutase is a candidate prognostic marker for glioblastoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 정지혜 | - |
dc.contributor.AlternativeAuthor | 문민정 | - |
dc.contributor.AlternativeAuthor | 김영임 | - |
dc.contributor.AlternativeAuthor | 김진현 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.contributor.AlternativeAuthor | 김채용 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
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