The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas

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Paek, Sun Ha; Kim, Dong Gyu; Park, Chul-Kee; Phi, Ji Hoon; Kim, Young Yim; Im, Soo Young; Kim, Jeong Eun; Park, Sung-Hye; Jung, Hee-Won

Issue Date
Spandidos Publications
Oncol Rep 16:49-56,2006
microcystic meningiomamicrocyst formationperitumoral edemaMMP-9TIMP-1MMP-9/TIMP-1 ratio
We studied the expression of matrix metalloproteinases
(MMP) and tissue inhibitors of matrix metalloproteinase
(TIMP) in microcystic meningiomas to investigate
a possible underlying mechanism for the development of
microcysts and of peritumoral edema, which are frequent
characteristics of this rare subtype. Between October 1995
and June 2004, 10 of 19 patients who had histologically
confirmed pure microcystic meningiomas were enrolled in
the study. Six patients with meningothelial meningiomas,
three with atypical meningiomas, and one with a transitional
meningioma were included as a control group. Immunohistochemistry
with paraffin blocks and real-time RT-PCR analysis
for MMP-2, MMP-9, TIMP-1, TIMP-2 and vascular endothelial
growth factor (VEGF) were performed using stored
frozen tissues. Compared with the control group, MMP-9
was invariably and highly expressed in immunohistochemical
staining of microcystic meningiomas. MMP-2, TIMP-1,
TIMP-2 and VEGF were weakly expressed or not expressed
in both microcystic and non-microcystic meningiomas. Realtime
RT-PCR showed increased ratios of MMP-9 to TIMP-1
in microcystic meningiomas compared with the control group
(55.855±106.353 vs. 1.858±2.575, respectively; p=0.00). The
expression of MMP-2 (0.72±1.20 vs. 2.54±3.01, p=0.01) and
TIMP-2 (1.22±1.67 vs. 1.61±1.82, p=0.02) was higher in the
control group. The results suggested that the increased ratio of
MMP-9 to TIMP-1 might be associated with the formation of
microcysts and peritumoral edema in microcystic meningioma.
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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