Publications
Detailed Information
Immobilization of bone morphogenetic protein-2 on a nanofibrous chitosan membrane for enhanced guided bone regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yoon Jeong | - |
dc.contributor.author | Kim, Kyung Hwa | - |
dc.contributor.author | Lee, Jue Yeon | - |
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Min, Byung Moo | - |
dc.contributor.author | Chung, Chong Pyoung | - |
dc.date.accessioned | 2011-10-18T05:32:11Z | - |
dc.date.available | 2011-10-18T05:32:11Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | Biotechnol. Appl. Biochem. 43,17–24 | en |
dc.identifier.issn | 0885-4513 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74276 | - |
dc.description.abstract | BMP-2 (bone morphogenetic protein-2) has been used in promoting bone formation and, in combination with various delivery carriers, in bone regeneration or bone tissue-engineering practice. In the present study, BMP-2 was immobilized directly on a GBR (guided bone-regenerative) membrane surface made of chitosan nanofibres, providing a bioactive surface that can enhance bone-regeneration capacity. The BMP-2-conjugated membrane surface retained bioactivity for up to 4 weeks of incubation, as well as holding over 50% of the initial BMP-2 attached. The BMP-2-conjugated surface increased osteoblastic cell attachment in accordance with the amount of BMP-2 conjugated. In addition, the BMP-2-conjugated chitosan membrane significantly promoted cell proliferation, alkaline phosphatase activity, as well as calcium deposition when compared with BMP-2-adsorbed membrane, indicating a stable localization of BMP-2 at the surface of the chitosan membrane. Taking these findings together, the conjugation of BMP-2 on a chitosan nanofibrous membrane would seen to be applicable for inducing significant and localized bone formation in future GBR procedures. | en |
dc.description.sponsorship | This work was supported by the grant from the Korea Science and Engineering Foundation(KOSEF) though the Intellectual Biointerface Engineering(IBEC) at Seoul National University. | en |
dc.language.iso | en | en |
dc.publisher | Portland Press | en |
dc.subject | bone morphogenetic protein | en |
dc.subject | chitosan membrane | en |
dc.subject | guided bone regeneration | en |
dc.subject | immobilization | en |
dc.title | Immobilization of bone morphogenetic protein-2 on a nanofibrous chitosan membrane for enhanced guided bone regeneration | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박윤정 | - |
dc.contributor.AlternativeAuthor | 김경화 | - |
dc.contributor.AlternativeAuthor | 이주연 | - |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.contributor.AlternativeAuthor | 민병무 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.