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Bone Morphogenetic Protein 2-induced MAPKs Activation Is Independent of the Smad1/5 Activation

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dc.contributor.authorJun, Ji Hae-
dc.contributor.authorRyoo, Hyun-Mo-
dc.contributor.authorWoo, Kyung Mi-
dc.contributor.authorKim, Gwan-Shik-
dc.contributor.authorBaek, Jeong-Hwa-
dc.date.accessioned2011-10-18T08:29:10Z-
dc.date.available2011-10-18T08:29:10Z-
dc.date.issued2009-06-
dc.identifier.citationInt J Oral Bio. 2009;34:115-21en
dc.identifier.issn1226-7155-
dc.identifier.urihttps://hdl.handle.net/10371/74295-
dc.description.abstractBone morphogenetic protein (BMP) 2 is a potent osteogenic factor. Although both Smad1/5 and mitogenactivated protein kinases (MAPKs) are activated by BMP2, the hierarchical relationship between them is unclear. In this study, we examined if BMP2-stimulated MAPK activation is regulated by Smad1/5 or vice versa. When C2C12 cells were treated with BMP2, the activation of extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun-N-terminal kinase was evident within 5 min. The knockdown of both Smad1 and Smad5 by small interfering RNA did not affect the activation of these MAPKs. In addition, neither the overexpression of Smad1 nor Smad5 induced ERK activation. When ERK activation was induced by constitutively active MEK1 expression, the protein level and activation of Smad1 increased. Furthermore, the inhibition of constitutively active BMP receptor type IB-induced ERK activation significantly suppressed Smad1 activation. These results indicate that Smad1/5 activation is not necessary for BMP2-induced MAPK activation and also that ERK positively regulates Smad1 activation.en
dc.description.sponsorship이 논문은 2006년도 정부재원(교육인적자원부 학술연구조성사업비)으로 한국학술진흥재단의 지원을 받아 연구되었음(KRF-2006-000-E00093).en
dc.language.isokoen
dc.publisherKorean Acadamy of Oral Biologyen
dc.subjectBone morphogenetic protein 2en
dc.subjectSmad1en
dc.subjectSmad5en
dc.subjectMitogen-activated protein kinase (MAPK)en
dc.titleBone Morphogenetic Protein 2-induced MAPKs Activation Is Independent of the Smad1/5 Activationen
dc.typeArticleen
dc.contributor.AlternativeAuthor전지혜-
dc.contributor.AlternativeAuthor류현모-
dc.contributor.AlternativeAuthor우경미-
dc.contributor.AlternativeAuthor김관식-
dc.contributor.AlternativeAuthor백정화-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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