수용성환원키토산 배합 양치액의 구취 형성 억제 효과

Abstract

Objectives: This study examined the effects of newly developed water-soluble reduced chitosan on the volatile sulfur compounds induced by 4-day plaque regrowth. Methods: 1.0% water-soluble reduced chitosan with a pH ranging from 6.0 to 6.5, a molecular weight between 3,000 and 5,000 Da, and a 70% of degree of deacetylation was used. The amounts of volatile sulfur compounds in the mouth air were measured in vivo. Twelve dental students volunteered to participate in this double blind, randomized, 4-day plaque regrowth study. The subjects were divided into three groups and asked to rinse with the allocated mouthrinse solution and refraining from all mechanical oral hygiene measures. Results: The chitosan mouthwash reduced significantly the amounts of hydrogen sulfide in the mouth air compared to DW. Conclusions: The water-soluble reduced chitosan exhibited significant malodor-reducing activity during the 4-day plaque regrowth experiment.