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Age-Related Changes in Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity and Protein Level in the Gerbil Hippocampal CA1 Region
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Lee, Choong Hyun | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Won, Moo Ho | - |
dc.contributor.author | Sung, Je Kyeong | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Lee, Heungshik S. | - |
dc.contributor.author | Lee, In Se | - |
dc.date.accessioned | 2009-08-24T08:37:27Z | - |
dc.date.available | 2009-08-24T08:37:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | J. Vet. Med. Sci. 69: 1131-1136 | en |
dc.identifier.issn | 0916-7250 (print) | - |
dc.identifier.issn | 1347-7439 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/7610 | - |
dc.description.abstract | Microglia are evenly distributed throughout the brain parenchyma. They respond rapidly to a variety of alterations in the microenvironment of the brain and act as sensors for pathological events in the brain. In the present study, we investigated the age-dependent changes in the immunoreactivity and protein level of ionized calcium-binding adapter molecule 1 (Iba-1), a microglial marker, in the CA1 region of the gerbil hippocampus. Iba-1 immunoreactive microglia were detected in the hippocampal CA1 region of the postnatal month 1 (PM 1) group. Iba-1 positive microglia were morphologically inactive between the PM 1 and PM 12 stages. Some Iba-1 immunoreactive microglia were present in the active form in the hippocampal CA1 region of the PM 18 and PM 24 groups. The Iba-1 protein levels in hippocampal CA1 homogenates were decreased in the PM 1 through PM 6 groups and increased in an age-dependent manner thereafter. These results suggest that Iba-1 immunoreactive microglia in the active form were detected in the hippocampal CA1 region in the PM 18 and PM 24 groups. This result may be associated with an age-dependent susceptibility to neurodegenerative diseases associated with the hippocampus. | en |
dc.language.iso | en | en |
dc.publisher | Japanese Society of Veterinary Science | en |
dc.subject | age | en |
dc.subject | gerbil | en |
dc.subject | hippocampal CA1 region | en |
dc.subject | ionized calcium-binding adapter molecule 1 | en |
dc.subject | microglia | en |
dc.title | Age-Related Changes in Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity and Protein Level in the Gerbil Hippocampal CA1 Region | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 이충현 | - |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.contributor.AlternativeAuthor | 원무호 | - |
dc.contributor.AlternativeAuthor | 성제경 | - |
dc.contributor.AlternativeAuthor | 윤여성 | - |
dc.contributor.AlternativeAuthor | 이흥식 | - |
dc.contributor.AlternativeAuthor | 이인세 | - |
dc.identifier.doi | 10.1292/jvms.69.1131 | - |
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