Publications
Detailed Information
The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Song, Young Rim | - |
dc.contributor.author | Kim, Hyo Sang | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Yoon, Hyung Jin | - |
dc.contributor.author | Park, Minseon | - |
dc.contributor.author | Kim, Yonsu | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.date.accessioned | 2012-05-22T01:43:49Z | - |
dc.date.available | 2012-05-22T01:43:49Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 ; S50-S56 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76198 | - |
dc.description.abstract | Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subjects. We grouped 1,208 normotensive subjects by the criterion of the highest quintile value of serum bilirubin, 1.1 mg/dL. The incidence of hypertension was higher in group 1 with bilirubin less than 1.1 mg/dL than in group 2 with bilirubin 1.1 mg/dL or more (186/908 vs. 43/300, p=0.018). The relative risk for hypertension was 0.71 (95% confidence interval, 0.51-0.99), p=0.048 in group 2 compared to group 1 by Cox`s proportional hazard model. Among the groups stratified by gender, smoking, and liver function status, the group 2 showed a lower risk of hypertension in females and in non-smokers. In conclusion, a mild increase within the physiological range of serum bilirubin concentration was negatively correlated with the incidence of hypertension. The effect of bilirubin on the development of hypertension was more evident in females and in non-smokers. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Hypertension | ko_KR |
dc.subject | Hyperbilirubinemia | ko_KR |
dc.subject | Risk Factor | ko_KR |
dc.title | The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 송영림 | - |
dc.contributor.AlternativeAuthor | 김효상 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 윤형진 | - |
dc.contributor.AlternativeAuthor | 박민선 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 김성원 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.S1.S50 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Kitiyakara C, 1998, CURR OPIN NEPHROL HY, V7, P531 | - |
dc.description.citedreference | Villard PH, 1998, PHARMACOL TOXICOL, V82, P74 | - |
dc.description.citedreference | Swei A, 1997, HYPERTENSION, V30, P1628 | - |
dc.description.citedreference | Laursen JB, 1997, CIRCULATION, V95, P588 | - |
dc.description.citedreference | Johnson RA, 1996, AM J PHYSIOL-HEART C, V271, pH1132 | - |
dc.description.citedreference | Rajagopalan S, 1996, J CLIN INVEST, V97, P1916 | - |
dc.description.citedreference | SUZUKI H, 1995, HYPERTENSION, V25, P1083 | - |
dc.description.citedreference | Zucker SD, 2004, HEPATOLOGY, V40, P827, DOI 10.1002/hep.20407 | - |
dc.description.citedreference | Pflueger A, 2005, AM J PHYSIOL-RENAL, V288, pF552, DOI 10.1152/ajprenal.00278.2004 | - |
dc.description.citedreference | Lanone S, 2005, FASEB J, V19, P1890, DOI 10.1096/fj.04-2683fje | - |
dc.description.citedreference | Botros FT, 2005, KIDNEY INT, V68, P2745 | - |
dc.description.citedreference | Pradhan A, 2006, AM J NEPHROL, V26, P552, DOI 10.1159/000098001 | - |
dc.description.citedreference | Kirkby KA, 2006, AM J PHYSIOL-RENAL, V290, pF563, DOI 10.1152/ajprenal.00220.2005 | - |
dc.description.citedreference | Vera T, 2007, AM J PHYSIOL-REG I, V292, pR1472, DOI 10.1152/ajpregu.00601.2006 | - |
dc.description.citedreference | Hong JS, 2007, MATURITAS, V56, P411, DOI 10.1016/j.maturitas.2006.11.004 | - |
dc.description.citedreference | Rhee MY, 2007, AM J HYPERTENS, V20, P637, DOI 10.1016/j.amjhyper.2006.12.017 | - |
dc.description.citedreference | Motterlini R, 1998, CIRC RES, V83, P568 | - |
dc.description.citedreference | Papadakis JA, 1999, AM J HYPERTENS, V12, P673 | - |
dc.description.citedreference | Nicod L, 2000, MOL CELL BIOCHEM, V203, P33 | - |
dc.description.citedreference | Wiesel P, 2001, CIRC RES, V88, P1088 | - |
dc.description.citedreference | Sabaawy HE, 2001, HYPERTENSION, V38, P210 | - |
dc.description.citedreference | Van Hoydonck PGA, 2001, INT J EPIDEMIOL, V30, P1465 | - |
dc.description.citedreference | Ndisang JF, 2002, HYPERTENSION, V40, P315, DOI 10.1161/01.HYP.0000028488.71068.16 | - |
dc.description.citedreference | Reckelhoff JF, 2003, AM J PHYSIOL-REG I, V284, pR893, DOI 10.1152/ajpregu.00491.2002 | - |
dc.description.citedreference | Goodman AI, 2003, EXP BIOL MED, V228, P454 | - |
dc.description.citedreference | Novotny L, 2003, EXP BIOL MED, V228, P568 | - |
dc.description.citedreference | Toth B, 2003, ARCH SURG-CHICAGO, V138, P1375 | - |
dc.description.citedreference | JOHNSON RA, 1995, HYPERTENSION, V25, P166 | - |
dc.description.citedreference | KUMAR KV, 1993, FREE RADICAL RES COM, V19, P59 | - |
dc.description.citedreference | FREI B, 1991, BIOCHEM J, V277, P133 | - |
dc.description.citedreference | STOCKER R, 1987, SCIENCE, V235, P1043 | - |
dc.description.citedreference | SANO K, 1985, PEDIATR RES, V19, P587 | - |
dc.description.citedreference | WHITE GL, 1981, CLIN CHEM, V27, P1140 | - |
dc.description.tc | 3 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.