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National surveillance of antifungal susceptibility of Candida species in South Korean hospitals

Cited 6 time in Web of Science Cited 9 time in Scopus
Authors
Yoo, Jae Il; Choi, Chi Won; Lee, Kyeong Min; Kim, Young Kwon; Kim, Eui-Chong; Yun, Seon Han; Kim, Bong Su; Lee, Yeong Seon; Joo, Sae Ik; Kim, Tae Un
Issue Date
2009
Publisher
TAYLOR & FRANCIS LTD
Citation
MEDICAL MYCOLOGY; Vol.47 5; 554-558
Keywords
Candida speciesnon-tertiary hospitalstertiary hospitalsantifungal susceptibility
Abstract
We investigated the species distribution and antifungal susceptibility of Candida isolates from tertiary and non-tertiary hospitals in South Korea from 2002-2004. Of the 612 Candida isolates that were collected, Candida albicans, C. parapsilosis, C. tropicalis, and C. glabrata occurred most frequently, accounting for 97.3% and 96.8% of the isolates in tertiary and non-tertiary hospitals, respectively. C. albicans was the most common isolate, but the incidence of non-C. albicans Candida species was higher than that of C. albicans in tertiary hospitals. The Candida species had much lower MIC(90) to voriconazole (tertiary hospitals: 0.5 mu g/ml, non-tertiary hospitals: 0.25 mu g/ml) than to fluconazole (tertiary hospitals: 8 mu g/ml, non-tertiary hospitals: 4 mu g/ml). The MIC(90) of Candida isolates to 5-flucytosine in non-tertiary hospitals was two times higher than that observed in tertiary facilities. The C. glabrata isolates showed a tendency toward strong resistance to fluconazole, but C. parapsilosis isolates were susceptible to all of the evaluated antifungal agents. Voriconazole showed strong in vitro activity against Candida species, especially C. krusei, which is resistant to fluconazole and 5-flucytosine. To our knowledge, this is the first report of Candida antifungal susceptibility that includes non-tertiary hospitals in South Korea.
ISSN
1369-3786
Language
English
URI
https://hdl.handle.net/10371/76204
DOI
https://doi.org/10.1080/13693780802354037
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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