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Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
DC Field | Value | Language |
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dc.contributor.author | Cui, Yanji | - |
dc.contributor.author | Wu, Jinji | - |
dc.contributor.author | Park, Deok-Bae | - |
dc.contributor.author | Jung, Sung-Cherl | - |
dc.contributor.author | Hong, Jeong Yun | - |
dc.contributor.author | Lee, Sun-Ryung | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Eun, Su-Yong | - |
dc.contributor.author | Kim, Soon-Jong | - |
dc.contributor.author | Kim, Se-Jae | - |
dc.contributor.author | Maeng, Young-Hee | - |
dc.date.accessioned | 2012-05-22T02:40:53Z | - |
dc.date.available | 2012-05-22T02:40:53Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | BIOLOGICAL & PHARMACEUTICAL BULLETIN; Vol.33 11; 1814-1821 | ko_KR |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76211 | - |
dc.description.abstract | A growing body of evidence suggests that nobiletin (5,6,7,8,3`,4`-hexamethoxy flavone) from the peel of citrus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated. Since nobiletin has shown anti-inflammatory effects in several tissues, we investigated whether nobiletin suppresses excessive microglial activation implicated in neurotoxicity in lipopolysaccharide (LPS)-stimulated BV-2 microglia cell culture models. Release of nitric oxide (NO), the major inflammatory mediator in microglia, was markedly suppressed in a dose-dependent manner following nobiletin treatment (1-50 mu M) in LPS-stimulated BV-2 microglia cells. The inhibitory effect of nobiletin was similar to that of minocycline, a well-known microglial inactivator. Nobiletin significantly inhibited the release of the pro-inflammatory cytokine tumor necrosis factor (TNF-alpha) and interleukin-1 beta (IL-1 beta). LPS-induced phosphorylations of extracellular signal-regulated kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), and p38 mitogen-activated protein kinases (MAPKs) were also significantly inhibited by nobiletin treatment. In addition, nobiletin markedly inhibited the LPS-induced pro-inflammatory transcription factor nuclear factor kappa B (NF-kappa B) signaling pathway by suppressing nuclear NF-kappa B translocation from the cytoplasm and subsequent expression of NF-kappa B in the nucleus. Taken together, these results may contribute to further exploration of the therapeutic potential and molecular mechanism of nobiletin in relation to neuroinflammation and neurodegenerative diseases. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PHARMACEUTICAL SOC JAPAN | ko_KR |
dc.subject | nobiletin | ko_KR |
dc.subject | neuroinflammation | ko_KR |
dc.subject | neurodegeneration | ko_KR |
dc.subject | citrus | ko_KR |
dc.subject | nuclear factor kappa B | ko_KR |
dc.subject | microglia | ko_KR |
dc.title | Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 우진지 | - |
dc.contributor.AlternativeAuthor | 정성철 | - |
dc.contributor.AlternativeAuthor | 맹양희 | - |
dc.contributor.AlternativeAuthor | 이선령 | - |
dc.contributor.AlternativeAuthor | 김세재 | - |
dc.contributor.AlternativeAuthor | 홍정윤 | - |
dc.contributor.AlternativeAuthor | 박덕배 | - |
dc.contributor.AlternativeAuthor | 김순종 | - |
dc.contributor.AlternativeAuthor | 은수용 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.citation.journaltitle | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
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dc.description.tc | 2 | - |
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