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Ca(2+) signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells
DC Field | Value | Language |
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dc.contributor.author | Nam, Joo Hyun | - |
dc.contributor.author | Shin, Dong Hun | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Min, Jung Eun | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.date.accessioned | 2012-05-22T06:23:38Z | - |
dc.date.available | 2012-05-22T06:23:38Z | - |
dc.date.issued | 2010-01-31 | - |
dc.identifier.citation | MOLECULES AND CELLS; Vol.29 1; 85-91 | ko_KR |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76237 | - |
dc.description.abstract | Lysophospholipids (LPLs) such as lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are chemotactic for lymphocytes, and increases of in cytosolic [Ca(2+)] signal the regulation of lymphocyte activation and migration. Here, the authors investigated the effects of LPA and S1P on [Ca(2+)](c) in mouse B cell lines (WEHI-231 and Bal-17) and primary B cells isolated from mouse spleen and bone marrow, and focused on the modulation of store-operated Ca(2+) entry (SOCE) by LPLs. In Bal-17 (a mature B cell line) both LPA and S1P induced a transient [Ca(2+)](c) increase via a phospholipase C pathway. In addition, pretreatment with LPLs was found to augment thapsigargin-induced SOCE in Bal-17 cells. However, in WEHI-231 (an immature B cell line) LPLs had no significant effect on [Ca(2+)](c) or SOCE. Furthermore, in freshly isolated splenic B cells (SBCs) and bone marrow B cells (BMBCs), LPLs induced only a small increase in [Ca(2+)](c). Interestingly, however, pretreatment with LPLs markedly increased SOCE in primary B cells, and this augmentation was more prominent in BMBCs than SBCs. The unidirectional influx of Ca(2+) was measured using Ba(2+) as a surrogate ion. Similarly, Ba(2+) influx was also found to be markedly increased by LPLs in SBCs and BMBCs. Summarizing, LPLs were found to strongly augment SOCE-mediated Ca(2+)-signaling in mouse B cells. However, unlike the mature Bal-17 cell line, PLC-dependent Ca(2+) release was insignificant in primary B cells and inWEHI-231. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | ko_KR |
dc.subject | B cell | ko_KR |
dc.subject | Ca(2+) signal | ko_KR |
dc.subject | lysophosphatidic acid | ko_KR |
dc.subject | sphingosine 1-phosphate | ko_KR |
dc.subject | store-operated Ca(2+) influx | ko_KR |
dc.title | Ca(2+) signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 남주현 | - |
dc.contributor.AlternativeAuthor | 이상규 | - |
dc.contributor.AlternativeAuthor | 신동훈 | - |
dc.contributor.AlternativeAuthor | 민정은 | - |
dc.contributor.AlternativeAuthor | 전주홍 | - |
dc.contributor.AlternativeAuthor | 김성준 | - |
dc.identifier.doi | 10.1007/s10059-010-0020-4 | - |
dc.citation.journaltitle | MOLECULES AND CELLS | - |
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