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Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress

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dc.contributor.authorJeong, Eui Man-
dc.contributor.authorKim, Chai-Wan-
dc.contributor.authorJang, Gi-Yong-
dc.contributor.authorCho, Sung-Yup-
dc.contributor.authorShin, Dong-Myung-
dc.contributor.authorKim, In-Gyu-
dc.contributor.authorJeon, Ju-Hong-
dc.date.accessioned2012-05-22T07:01:00Z-
dc.date.available2012-05-22T07:01:00Z-
dc.date.issued2009-02-18-
dc.identifier.citationFEBS LETTERS; Vol.583 4; 648-654ko_KR
dc.identifier.issn0014-5793-
dc.identifier.urihttps://hdl.handle.net/10371/76245-
dc.description.abstractTransglutaminase 2 (TG2) is a calcium-dependent enzyme that catalyzes the transamidation reaction. Conflicting pieces of evidence have been reported on the role of TG2 in apoptosis. In this report, we showed that TG2 increased in response to low level of oxidative stress, whereas TG2 diminished under high stress conditions. Monitoring TG2 expression, activity and calcium concentration in cells treated with A23187 revealed that the initial rise of calcium activates TG2 but subsequent calcium-overload induces degradation of TG2 via calcium-mediated polyubiquitination. These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectUbiquitinationko_KR
dc.subjectProteasomal degradationko_KR
dc.subjectOxidative stressko_KR
dc.subjectTransglutaminase 2ko_KR
dc.subjectCalcium-overloadko_KR
dc.titleDegradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stressko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor정의만-
dc.contributor.AlternativeAuthor김채완-
dc.contributor.AlternativeAuthor조성엽-
dc.contributor.AlternativeAuthor장기용-
dc.contributor.AlternativeAuthor전주홍-
dc.contributor.AlternativeAuthor김인규-
dc.contributor.AlternativeAuthor신동명-
dc.identifier.doi10.1016/j.febslet.2009.01.032-
dc.citation.journaltitleFEBS LETTERS-
dc.description.citedreferenceShin DM, 2008, FASEB J, V22, P2498, DOI 10.1096/fj.07-095455-
dc.description.citedreferencePinkas DM, 2007, PLOS BIOL, V5, P2788, DOI 10.1371/journal.pbio.0050327-
dc.description.citedreferenceSarang Z, 2007, CELL DEATH DIFFER, V14, P1842, DOI 10.1038/sj.cdd.4402193-
dc.description.citedreferenceTang EHC, 2007, BRIT J PHARMACOL, V151, P15, DOI 10.1038/sj.bjp.0707190-
dc.description.citedreferenceHerman JF, 2006, ONCOGENE, V25, P3049, DOI 10.1038/sj.onc.1209324-
dc.description.citedreferenceBegg GE, 2006, J BIOL CHEM, V281, P12603, DOI 10.1074/jbc.M60014600-
dc.description.citedreferenceJones KT, 2005, REPRODUCTION, V130, P813, DOI 10.1530/rep.1.00710-
dc.description.citedreferenceShen CL, 2005, J BIOL CHEM, V280, P35967, DOI 10.1074/jbc.M505220200-
dc.description.citedreferenceFesus L, 2005, FEBS LETT, V579, P3297, DOI 10.1016/j.febslet.2005.03.063-
dc.description.citedreferenceAntonyak MA, 2004, J BIOL CHEM, V279, P41461, DOI 10.1074/jbc.M404976200-
dc.description.citedreferenceShin DM, 2004, J BIOL CHEM, V279, P15032, DOI 10.1074/jbc.M308734200-
dc.description.citedreferenceCohly H, 2004, IMMUNOL INVEST, V33, P407, DOI 10.1081/IMM-200038668-
dc.description.citedreferenceJeon JH, 2003, EMBO J, V22, P5273-
dc.description.citedreferenceMuller CSG, 2003, MOL CELL BIOCHEM, V250, P179-
dc.description.citedreferenceEsposito C, 2003, BIOCHEM J, V370, P205, DOI 10.1042/BJ20021390-
dc.description.citedreferenceLorand L, 2003, NAT REV MOL CELL BIO, V4, P140, DOI 10.1038/nrm1014-
dc.description.citedreferenceALLAMANPILLET N, 2003, J BIOL CHEM, V278, P48720-
dc.description.citedreferenceFesus L, 2002, TRENDS BIOCHEM SCI, V27, P534-
dc.description.citedreferenceLiu SP, 2002, P NATL ACAD SCI USA, V99, P2743, DOI 10.1073/pnas.042454899-
dc.description.citedreferenceAntonyak MA, 2001, J BIOL CHEM, V276, P33582-
dc.description.citedreferenceDe Laurenzi V, 2001, MOL CELL BIOL, V21, P148-
dc.description.citedreferenceFabbi M, 1999, CELL DEATH DIFFER, V6, P992-
dc.description.citedreferenceHan JA, 1999, J CANCER RES CLIN, V125, P89-
dc.description.citedreferenceZhang JW, 1998, J NEUROCHEM, V71, P240-
dc.description.citedreferenceLai TS, 1998, J BIOL CHEM, V273, P1776-
dc.description.citedreferenceNAORA H, 1995, BIOCHEM BIOPH RES CO, V211, P491-
dc.description.citedreferenceFESUS L, 1989, BIOCHEM J, V263, P843-
dc.description.citedreferenceFESUS L, 1987, FEBS LETT, V224, P104-
dc.description.tc4-
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