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Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Su-Hwa | - |
dc.contributor.author | Nam, Joo-Hyun | - |
dc.contributor.author | Kim, Byung Joo | - |
dc.contributor.author | Park, Eun Jung | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.contributor.author | So, Insuk | - |
dc.date.accessioned | 2012-05-22T07:34:36Z | - |
dc.date.available | 2012-05-22T07:34:36Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; Vol.1792 1; 33-38 | ko_KR |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76249 | - |
dc.description.abstract | Menthol, a naturally occurring compound from peppermint oil, binds and activates the TRPM8 Ca(2+)-permeable channel that exhibits abnormal expression patterns in prostate cancer, suggesting that TRPM8 links Ca(2+) transport pathways to tumor biology. We thus investigated the cellular responses of prostate cancer cells to menthol. Here we found that menthol increases [Ca(2+)]; via Ca(2+) influx mechanism(s) independent of TRPM8 in PC-3 cells. We demonstrated that menthol induces cell death at supramillimolar concentrations in PC-3 cells and the cell death is not suppressed by low extracellular Ca(2+) condition which indicates that menthol-induced cell death is not associated with Ca(2+) influx pathways. In addition, we showed that menthol increases a phosphorylated form of c-jun N-terminal kinase (JNK) in PC-3 cells through TRPM8-independent mechanisms. Thus, our data indicate that there is an apparent lack of causality between TRPM8 activation and menthol-induced cell death and that menthol can regulate TRPM8-independent Ca(2+)-transport and cellular processes. (C) 2008 Elsevier B.V. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE BV | ko_KR |
dc.subject | Menthol | ko_KR |
dc.subject | Ca(2+) | ko_KR |
dc.subject | TRPM8 | ko_KR |
dc.subject | Cell death | ko_KR |
dc.subject | Prostate cancer | ko_KR |
dc.title | Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김수화 | - |
dc.contributor.AlternativeAuthor | 김병주 | - |
dc.contributor.AlternativeAuthor | 소인석 | - |
dc.contributor.AlternativeAuthor | 전주홍 | - |
dc.contributor.AlternativeAuthor | 김성준 | - |
dc.contributor.AlternativeAuthor | 남주현 | - |
dc.contributor.AlternativeAuthor | 박은정 | - |
dc.identifier.doi | 10.1016/j.bbadis.2008.09.012 | - |
dc.citation.journaltitle | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.description.citedreference | Mahieu F, 2007, J BIOL CHEM, V282, P3325, DOI 10.1074/jbc.M605213200 | - |
dc.description.citedreference | De Marzo AM, 2007, NAT REV CANCER, V7, P256, DOI 10.1038/nrc2090 | - |
dc.description.citedreference | Bidaux G, 2007, J CLIN INVEST, V117, P1647, DOI 10.1172/JCI30168 | - |
dc.description.citedreference | Monteith GR, 2007, NAT REV CANCER, V7, P519, DOI 10.1038/nrc2171 | - |
dc.description.citedreference | Shen MM, 2007, CANCER RES, V67, P6535, DOI 10.1158/0008-5472.CAN-07-1271 | - |
dc.description.citedreference | Karashima Y, 2007, J NEUROSCI, V27, P9874, DOI 10.1523/JNEUROSCI.2221-07.2007 | - |
dc.description.citedreference | Patel T, 2007, J AM ACAD DERMATOL, V57, P873, DOI 10.1016/j.jaad.2007.04.008 | - |
dc.description.citedreference | Mckay DL, 2006, PHYTOTHER RES, V20, P619, DOI 10.1002/ptr.1936 | - |
dc.description.citedreference | VOETS T, 2007, HANDB EXP PHARM, V179, P329 | - |
dc.description.citedreference | Thebault S, 2005, J BIOL CHEM, V280, P39423, DOI 10.1074/M503544200 | - |
dc.description.citedreference | Rohacs T, 2005, NAT NEUROSCI, V8, P626, DOI 10.1038/nn1451 | - |
dc.description.citedreference | Zhang L, 2004, CANCER RES, V64, P8365 | - |
dc.description.citedreference | Behrendt HJ, 2004, BRIT J PHARMACOL, V141, P737, DOI 10.1038/sj.bjp.0705652 | - |
dc.description.citedreference | Henshall SM, 2003, CANCER RES, V63, P4196 | - |
dc.description.citedreference | Orrenius S, 2003, NAT REV MOL CELL BIO, V4, P552, DOI 10.1038/nrm1150 | - |
dc.description.citedreference | Morrison DK, 2003, ANNU REV CELL DEV BI, V19, P91, DOI 10.1146/annurev.cellbio.19.111401.091942 | - |
dc.description.citedreference | Peier AM, 2002, CELL, V108, P705 | - |
dc.description.citedreference | McKemy DD, 2002, NATURE, V416, P52, DOI 10.1038/nature719 | - |
dc.description.citedreference | Feldman BJ, 2001, NAT REV CANCER, V1, P34 | - |
dc.description.citedreference | Tsavaler L, 2001, CANCER RES, V61, P3760 | - |
dc.description.citedreference | GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440 | - |
dc.description.tc | 11 | - |
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