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Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes
DC Field | Value | Language |
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dc.contributor.author | Yea, Kyungmoo | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Yoon, Jong Hyuk | - |
dc.contributor.author | Kwon, Taewan | - |
dc.contributor.author | Lee, Byoung Dae | - |
dc.contributor.author | Lee, Seung Jae | - |
dc.contributor.author | Lee, Taehoon G. | - |
dc.contributor.author | Park, Ho Seon | - |
dc.contributor.author | Ohba, Motoi | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.contributor.author | Kim, Jong-In | - |
dc.contributor.author | Lee, Hae-Jeong | - |
dc.contributor.author | Kim, Jong Hyun | - |
dc.date.accessioned | 2012-05-22T07:55:41Z | - |
dc.date.available | 2012-05-22T07:55:41Z | - |
dc.date.issued | 2009-12-04 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY; Vol.284 49; 33833-33840 | ko_KR |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76252 | - |
dc.description.abstract | Glucose homeostasis is maintained by the orchestration of peripheral glucose utilization and hepatic glucose production, mainly by insulin. In this study, we found by utilizing a combined parallel chromatography mass profiling approach that lysophosphatidylcholine (LPC) regulates glucose levels. LPC was found to stimulate glucose uptake in 3T3-L1 adipocytes dose- and time-dependently, and this activity was found to be sensitive to variations in acyl chain lengths and to polar head group types in LPC. Treatment with LPC resulted in a significant increase in the level of GLUT4 at the plasma membranes of 3T3-L1 adipocytes. Moreover, LPC did not affect IRS-1 and AKT2 phosphorylations, and LPC-induced glucose uptake was not influenced by pretreatment with the PI 3-kinase inhibitor LY294002. However, glucose uptake stimulation by LPC was abrogated both by rottlerin (a protein kinase C delta inhibitor) and by the adenoviral expression of dominant negative protein kinase C delta. In line with its determined cellular functions, LPC was found to lower blood glucose levels in normal mice. Furthermore, LPC improved blood glucose levels in mouse models of type 1 and 2 diabetes. These results suggest that an understanding of the mode of action of LPC may provide a new perspective of glucose homeostasis. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | ko_KR |
dc.title | Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 예경무 | - |
dc.contributor.AlternativeAuthor | 김재윤 | - |
dc.contributor.AlternativeAuthor | 윤종혁 | - |
dc.contributor.AlternativeAuthor | 권태완 | - |
dc.contributor.AlternativeAuthor | 김종현 | - |
dc.contributor.AlternativeAuthor | 이병대 | - |
dc.contributor.AlternativeAuthor | 이해정 | - |
dc.contributor.AlternativeAuthor | 이승재 | - |
dc.contributor.AlternativeAuthor | 김종인 | - |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 백문창 | - |
dc.contributor.AlternativeAuthor | 박호선 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 서판길 | - |
dc.contributor.AlternativeAuthor | 류성호 | - |
dc.identifier.doi | 10.1074/jbc.M109.024869 | - |
dc.citation.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
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dc.description.tc | 4 | - |
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