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Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Young | - |
dc.contributor.author | Park, Jongmin | - |
dc.contributor.author | Oh, Bora | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Cheong, June-Won | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.contributor.author | Park, Seung Bum | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.contributor.author | Jeong, Tae-Sook | - |
dc.date.accessioned | 2012-05-22T08:47:15Z | - |
dc.date.available | 2012-05-22T08:47:15Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | BRITISH JOURNAL OF HAEMATOLOGY; Vol.146 3; 270-281 | ko_KR |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76257 | - |
dc.description.abstract | P>Bortezomib is a therapeutic proteasome inhibitor with antimyeloma activity and polyphenols are well known compounds that exert antiproliferative effects against tumuors. We attempted to co-treat myeloma cells with bortezomib and polyphenols, anticipating a synergistic effect. However, the anticancer activity of bortezomib was blocked by the polyphenols. The structural features of the polyphenols correlated strikingly with their antagonistic effect; in particular, the presence or absence of a vicinal diol moiety was the key element for effective blockage of the anticancer function of bortezomib. We speculated that the vicinal diols in the polyphenols interact with the boronic acid of bortezomib and convert the active triangular boronic acid of bortezomib to an inactive tetrahedral boronate, thus abolishing the antimyeloma activity of bortezomib. We confirmed this hypothesis by (11)B nuclear magnetic resonance spectroscopy and an in vitro assay on multiple myeloma (MM) cell lines and primary myeloma cells from patients. Based on these findings, restriction of the intake of natural polyphenols in foods or vitamin supplements during bortezomib treatment in MM patients should be considered. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | bortezomib | ko_KR |
dc.subject | multiple myeloma | ko_KR |
dc.subject | polyphenols | ko_KR |
dc.subject | drug-drug interaction | ko_KR |
dc.subject | vicinal diol | ko_KR |
dc.title | Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김태영 | - |
dc.contributor.AlternativeAuthor | 박종민 | - |
dc.contributor.AlternativeAuthor | 오보라 | - |
dc.contributor.AlternativeAuthor | 민현정 | - |
dc.contributor.AlternativeAuthor | 정태숙 | - |
dc.contributor.AlternativeAuthor | 이재훈 | - |
dc.contributor.AlternativeAuthor | 서철원 | - |
dc.contributor.AlternativeAuthor | 정준원 | - |
dc.contributor.AlternativeAuthor | 김효정 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 박승범 | - |
dc.contributor.AlternativeAuthor | 이동순 | - |
dc.identifier.doi | 10.1111/j.1365-2141.2009.07752.x | - |
dc.citation.journaltitle | BRITISH JOURNAL OF HAEMATOLOGY | - |
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dc.description.tc | 9 | - |
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