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Comparison of retinal nerve fibre layers between 11778 and 14484 mutations in Leber`s hereditary optic neuropathy

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dc.contributor.authorSeo, J. H.-
dc.contributor.authorHwang, J-M-
dc.contributor.authorPark, S. S.-
dc.date.accessioned2012-05-22T08:55:09Z-
dc.date.available2012-05-22T08:55:09Z-
dc.date.issued2010-01-
dc.identifier.citationEYE; Vol.24 1; 107-111ko_KR
dc.identifier.issn0950-222X-
dc.identifier.urihttps://hdl.handle.net/10371/76259-
dc.description.abstractPurpose To compare retinal nerve fibre layer (RNFL) thickness changes between mitochondrial DNA (mtDNA) mutations at nucleotides 11778 and 14484 in Leber`s hereditary optic neuropathy (LHON) using optical coherence tomography (OCT). Methods Thirty LHON patients with mtDNA mutations at nucleotides 11778 or 14484 underwent full ophthalmologic examinations including Stratus OCT. Patients were divided into four groups according to disease duration (early <= 6 months, late >6 months) and mtDNA mutation type (11778 and 14484), and their RNFL thicknesses were compared. Results Average RNFL thickness in the early 11778 group was significantly greater than that in the early 14484 group (P = 0.04). Average RNFL thickness in the late 11778 group was significantly less than that in the late 14484 group (P = 0.02). Quadrant analysis of the superior, nasal, and inferior quadrant RNFL thickness in the late 11778 group showed more severe RNFL atrophy than in the late 14484 group (P = 0.023, 0.015, 0.003, respectively). Conclusions RNFL thickness was significantly increased in the early stage and decreased in the late stage in the 11778 group than in the 14484 group. Eye (2010) 24, 107-111; doi: 10.1038/eye.2009.36; published online 27 February 2009ko_KR
dc.language.isoenko_KR
dc.publisherNATURE PUBLISHING GROUPko_KR
dc.subjectLeber`s hereditary optic neuropathyko_KR
dc.subjectretinal nerve fibre layer thicknessko_KR
dc.subjectoptical coherence tomographyko_KR
dc.titleComparison of retinal nerve fibre layers between 11778 and 14484 mutations in Leber`s hereditary optic neuropathyko_KR
dc.typeArticleko_KR
dc.identifier.doi10.1038/eye.2009.36-
dc.citation.journaltitleEYE-
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dc.description.tc2-
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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