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Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation

Cited 20 time in Web of Science Cited 20 time in Scopus
Authors
Hong, Ki Ho; Kim, Hyun Kyung; Kim, Ji-Eun; Jung, Jae Seol; Cho, Han-Ik; Han, Kyou-Sup
Issue Date
2009-09
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
BLOOD COAGULATION & FIBRINOLYSIS; Vol.20 6; 409-414
Keywords
disseminated intravascular coagulationimmature platelet fractionreticulated plateletthrombopoietin
Abstract
Although platelet count is a good parameter for the diagnosis of disseminated intravascular coagulation (DIC), a single measurement of platelet is not enough to reflect the ongoing platelet consumption because of compensatory synthesis of circulating platelet number. Increased thrombopoiesis owing to peripheral destruction is expected in patients with DIC. Reticulated platelet, measured as immature platelet fraction (IPF), and plasma thrombopoietin (TPO) are markers of platelet production. We investigated the potential usefulness of circulating IPF and TPO in 222 patients suspected of having DIC. Both IPF and TPO levels were significantly increased in overt DIC patients and well correlated with DIC score. IPF also correlated with fibrin-related marker such as fibrinogen degradation product and D-dimer. Both IPF and TPO showed better mortality prediction than platelet count with the multivariate logistic regression and Kaplan-Meier survival analysis. These results suggest that IPF and TPO are new potential candidates to detect the severity of DIC and to predict DIC mortality. Blood Coagul Fibrinolysis 20:409-414 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
ISSN
0957-5235
Language
English
URI
https://hdl.handle.net/10371/76280
DOI
https://doi.org/10.1097/MBC.0b013e32832b1866
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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