S-Space College of Medicine/School of Medicine (의과대학/대학원) Laboratory Medicine (검사의학전공) Journal Papers (저널논문_검사의학전공)
Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation
- Hong, Ki Ho; Kim, Hyun Kyung; Kim, Ji-Eun; Jung, Jae Seol; Cho, Han-Ik; Han, Kyou-Sup
- Issue Date
- LIPPINCOTT WILLIAMS & WILKINS
- BLOOD COAGULATION & FIBRINOLYSIS; Vol.20 6; 409-414
- disseminated intravascular coagulation; immature platelet fraction; reticulated platelet; thrombopoietin
- Although platelet count is a good parameter for the diagnosis of disseminated intravascular coagulation (DIC), a single measurement of platelet is not enough to reflect the ongoing platelet consumption because of compensatory synthesis of circulating platelet number. Increased thrombopoiesis owing to peripheral destruction is expected in patients with DIC. Reticulated platelet, measured as immature platelet fraction (IPF), and plasma thrombopoietin (TPO) are markers of platelet production. We investigated the potential usefulness of circulating IPF and TPO in 222 patients suspected of having DIC. Both IPF and TPO levels were significantly increased in overt DIC patients and well correlated with DIC score. IPF also correlated with fibrin-related marker such as fibrinogen degradation product and D-dimer. Both IPF and TPO showed better mortality prediction than platelet count with the multivariate logistic regression and Kaplan-Meier survival analysis. These results suggest that IPF and TPO are new potential candidates to detect the severity of DIC and to predict DIC mortality. Blood Coagul Fibrinolysis 20:409-414 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
- Files in This Item: There are no files associated with this item.