Publications
Detailed Information
Endothelial Function is Not Changed during Short-Term Withdrawal of Thyroxine in Patients with Differentiated Thyroid Cancer and Low Cardiovascular Risk
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Hyuk-Jae | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Choi, Dong Joo | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Jang, Hak C. | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.date.accessioned | 2012-05-23T00:50:26Z | - |
dc.date.available | 2012-05-23T00:50:26Z | - |
dc.date.issued | 2010-07-01 | - |
dc.identifier.citation | YONSEI MEDICAL JOURNAL; Vol.51 4; 492-498 | ko_KR |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76287 | - |
dc.description.abstract | Purpose: The incidence of differentiated thyroid cancer is increasing in young adults and females in Korea. Some of them experience short-term hypothyroidism in preparation for radioiodine (RAI) therapy, which can have a deleterious effect on the cardiovascular system. However, it is not clear if short-term hypothyroidism induces endothelial dysfunction in patients with low cardiovascular risk. Therefore, the aim of this study was to investigate whether short-term hypothyroidism is associated with endothelial dysfunction in patients with low cardiovascular risk. Materials and Methods: To evaluate the effect of short-term hypothyroidism on endothelial function in this group, we recruited fifteen female patients with low cardiovascular risk. We analyzed clinical, biochemical, and cardiovascular parameters at four time points: the last day on levothyroxine (LT4) at their usual thyroid-stimulating hormone (TSH)-suppressive doses (P1), 7 days (P2) & 4 weeks (P3) after withdrawal of LT4, and 8 weeks (P4) after replacement of the previous dose of LT4. A high resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia, and after sublingual nitroglycerin. Results: During short-term hypothyroidism (P3), serum concentrations of total cholesterol and low-density lipoprotein (LDL)-cholesterol were increased (p < 0.001 for each period). In spite of having worsened lipid states, serum high sensitivity C-reactive protein or flow-mediated vasodilatation, which is one of the surrogate markers of the endothelial function, did not change during short-term hypothyroidism. Conclusion: Short-term hypothyroidism induced worsening of metabolic parameters, but not enough to induce the endothelial dysfunction in patients with low cardiovascular risk. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | YONSEI UNIV COLLEGE MEDICINE | ko_KR |
dc.subject | Short-term hypothyroidism | ko_KR |
dc.subject | endothelial dysfunction | ko_KR |
dc.subject | radioactive iodine | ko_KR |
dc.subject | flow-mediated vasodilatation | ko_KR |
dc.subject | thyroid cancer | ko_KR |
dc.title | Endothelial Function is Not Changed during Short-Term Withdrawal of Thyroxine in Patients with Differentiated Thyroid Cancer and Low Cardiovascular Risk | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 김경원 | - |
dc.contributor.AlternativeAuthor | 임수 | - |
dc.contributor.AlternativeAuthor | 최성희 | - |
dc.contributor.AlternativeAuthor | 장혁재 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 장학철 | - |
dc.contributor.AlternativeAuthor | 조보윤 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.identifier.doi | 10.3349/ymj.2010.51.4.492 | - |
dc.citation.journaltitle | YONSEI MEDICAL JOURNAL | - |
dc.description.citedreference | *MIN HLTH WELF KOR, 2007, ANN REP NAT CANC REG | - |
dc.description.citedreference | Pacini F, 2006, EUR J ENDOCRINOL, V154, P787, DOI 10.1530/eje.1.02158 | - |
dc.description.citedreference | Owen PJD, 2006, J CLIN ENDOCR METAB, V91, P2126, DOI 10.1210/jc.2005-2108 | - |
dc.description.citedreference | Flynn RWV, 2006, J CLIN ENDOCR METAB, V91, P2159, DOI 10.1210/jc.2005-1833 | - |
dc.description.citedreference | Botella-Carretero J, 2006, THYROID, V16, P397 | - |
dc.description.citedreference | Smith BR, 2006, THYROID, V16, P109 | - |
dc.description.citedreference | Regalbuto C, 2006, J ENDOCRINOL INVEST, V29, P32 | - |
dc.description.citedreference | Lee WY, 2004, ARCH MED RES, V35, P540, DOI 10.1016/j.arcmed.2004.08.003 | - |
dc.description.citedreference | Chang HJ, 2004, CLIN CARDIOL, V27, P421 | - |
dc.description.citedreference | Miller VM, 2007, CURR VASC PHARMACOL, V5, P15 | - |
dc.description.citedreference | Duntas LH, 2007, EUR J ENDOCRINOL, V156, P13, DOI 10.1530/eje.1.02310 | - |
dc.description.citedreference | Nagasaki T, 2007, BIOMED PHARMACOTHER, V61, P167, DOI 10.1016/j.biopha.2006.10.008 | - |
dc.description.citedreference | Razvi S, 2007, J CLIN ENDOCR METAB, V92, P1715, DOI 10.1210/jc.2006-1869 | - |
dc.description.citedreference | Owen PJD, 2007, THYROID, V17, P519, DOI 10.1089/thy.2007.0051 | - |
dc.description.citedreference | Erbil Y, 2007, BRIT J SURG, V94, P1485, DOI 10.1002/bjs.5915 | - |
dc.description.citedreference | Pearce EN, 2008, J CLIN ENDOCR METAB, V93, P888, DOI 10.1210/jc.2007-1987 | - |
dc.description.citedreference | Warnholtz A, 2009, ATHEROSCLEROSIS, V204, P216, DOI 10.1016/j.atherosclerosis.2008.08.003 | - |
dc.description.citedreference | Biondi B, 2004, ENDOCRINE, V24, P1 | - |
dc.description.citedreference | Botella-Carretero JI, 2004, ENDOCR-RELAT CANCER, V11, P345 | - |
dc.description.citedreference | Monzani F, 2004, J CLIN ENDOCR METAB, V89, P2099, DOI 10.1210/jc.2003-031669 | - |
dc.description.citedreference | Papaioannou GI, 2004, METABOLISM, V53, P278, DOI 10.1016/j.metabol.2003.10.003 | - |
dc.description.citedreference | DIPAOLA R, 2004, ITAL HEART J, V5, P857 | - |
dc.description.citedreference | GUANGDA X, 2004, CLIN ENDOCRINOL, V61, P400 | - |
dc.description.citedreference | FUSTER V, 2004, TXB MED, P383 | - |
dc.description.citedreference | Taddei S, 2003, J CLIN ENDOCR METAB, V88, P3731, DOI 10.1210/jc.2003-030039 | - |
dc.description.citedreference | Christ-Crain M, 2003, ATHEROSCLEROSIS, V166, P379 | - |
dc.description.citedreference | CONETTI MC, 2002, J AM COLL CARDIOL, V39, P257 | - |
dc.description.citedreference | Raitakari OT, 2000, BRIT J CLIN PHARMACO, V50, P397 | - |
dc.description.citedreference | Schachinger V, 2000, CIRCULATION, V101, P1899 | - |
dc.description.citedreference | SUWAIDI JA, 2000, CIRCULATION, V101, P948 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.