Browse

High Viremia, Prolonged Lamivudine Therapy and Recurrent Hepatocellular Carcinoma Predict Posttransplant Hepatitis B Recurrence dagger

Cited 36 time in Web of Science Cited 41 time in Scopus
Authors
Chun, J.; Kim, W.; Lee, K. L.; Kim, B. G.; Suh, K. -S.; Park, K. U.; Yoon, J. -H.; Lee, H. S.; Kim, Y. J.; Yi, N. -J.
Issue Date
2010-07
Publisher
WILEY-BLACKWELL
Citation
AMERICAN JOURNAL OF TRANSPLANTATION; Vol.10 7; 1649-1659
Keywords
Hepatocellular carcinomaliver transplantationmutationrecurrenceviral hepatitis
Abstract
Hepatitis B virus (HBV) recurrence following orthotopic liver transplantation (OLT) is generally preventable by prophylaxis with hepatitis B immunoglobulin (HBIG) and lamivudine (LAM). However, HBV recurrence sometimes develops despite prophylaxis. This study assessed posttransplant outcomes and identified predictors of HBV recurrence. We analyzed the outcomes of 209 consecutive patients positive for hepatitis B surface antigen who underwent OLT, who received either combination prophylaxis with HBIG and LAM (89.0%) or HBIG monoprophylaxis (11.0%). The median follow-up was 36.8 months (range, 1.0-84.4). Posttransplant HBV recurrence occurred in 22 patients (10.5%), including 13 patients with drug-resistant mutations. HBV recurrence was observed in six patients after hepatocellular carcinoma (HCC) recurrence. Independent predictors of HBV recurrence were recurrent HCC (p < 0.001), LAM therapy > 1.5 years (p = 0.001) and high HBV DNA titers (>= 105 copies/mL) at OLT (p = 0.036). In conclusion, high viremia at OLT and prolonged exposure to LAM should be further stressed as main predictors of HBV recurrence.
ISSN
1600-6135
Language
English
URI
http://hdl.handle.net/10371/76295
DOI
https://doi.org/10.1111/j.1600-6143.2010.03162.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse